دورية أكاديمية

Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium

التفاصيل البيبلوغرافية
العنوان: Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium
المؤلفون: Satria P. Sajuthi, Peter DeFord, Yingchun Li, Nathan D. Jackson, Michael T. Montgomery, Jamie L. Everman, Cydney L. Rios, Elmar Pruesse, James D. Nolin, Elizabeth G. Plender, Michael E. Wechsler, Angel C. Y. Mak, Celeste Eng, Sandra Salazar, Vivian Medina, Eric M. Wohlford, Scott Huntsman, Deborah A. Nickerson, Soren Germer, Michael C. Zody, Gonçalo Abecasis, Hyun Min Kang, Kenneth M. Rice, Rajesh Kumar, Sam Oh, Jose Rodriguez-Santana, Esteban G. Burchard, Max A. Seibold
المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
بيانات النشر: Nature Portfolio, 2020.
سنة النشر: 2020
المجموعة: LCC:Science
مصطلحات موضوعية: Science
الوصف: ACE2 and TMPRSS2 have received recent attention as entry factors for SARS-CoV-2. Here the authors analyze nasal airway transcriptome data from 695 children determining ACE2 and TMPRSS2 expression is induced by viral and type2 inflammation, respectively, and both exhibit eQTLs that vary across world populations.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-020-18781-2
URL الوصول: https://doaj.org/article/5998991851af4757adcf82673111f6e4
رقم الأكسشن: edsdoj.5998991851af4757adcf82673111f6e4
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20411723
DOI:10.1038/s41467-020-18781-2