دورية أكاديمية
Exposure to PM2.5 Metal Constituents and Liver Cancer Risk in REVEAL-HBV
| العنوان: | Exposure to PM2.5 Metal Constituents and Liver Cancer Risk in REVEAL-HBV |
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| المؤلفون: | Tzu-Yi Lu, Chih-Da Wu, Yen-Tsung Huang, Yu-Cheng Chen, Chien-Jen Chen, Hwai-I Yang, Wen-Chi Pan |
| المصدر: | Journal of Epidemiology, Vol 34, Iss 2, Pp 87-93 (2024) |
| بيانات النشر: | Japan Epidemiological Association, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | fine particulate matter, metal constituents, liver cancer, taiwan, Medicine (General), R5-920 |
| الوصف: | Background: Ambient particulate matter is classified as a human Class 1 carcinogen, and recent studies found a positive relationship between fine particulate matter (PM2.5) and liver cancer. Nevertheless, little is known about which specific metal constituent contributes to the development of liver cancer. Objective: To evaluate the association of long-term exposure to metal constituents in PM2.5 with the risk of liver cancer using a Taiwanese cohort study. Methods: A total of 13,511 Taiwanese participants were recruited from the REVEAL-HBV in 1991–1992. Participants’ long-term exposure to eight metal constituents (Ba, Cu, Mn, Sb, Zn, Pb, Ni, and Cd) in PM2.5 was based on ambient measurement in 2002–2006 followed by a land-use regression model for spatial interpolation. We ascertained newly developed liver cancer (ie, hepatocellular carcinoma [HCC]) through data linkage with the Taiwan Cancer Registry and national health death certification in 1991–2014. A Cox proportional hazards model was utilized to assess the association between exposure to PM2.5 metal component and HCC. Results: We identified 322 newly developed HCC with a median follow-up of 23.1 years. Long-term exposure to PM2.5 Cu was positively associated with a risk of liver cancer. The adjusted hazard ratio (HR) was 1.13 (95% confidence interval [CI], 1.02–1.25; P = 0.023) with one unit increment on Cu normalized by PM2.5 mass concentration in the logarithmic scale. The PM2.5 Cu-HCC association remained statistically significant with adjustment for co-exposures to other metal constituents in PM2.5. Conclusion: Our findings suggest PM2.5 containing Cu may attribute to the association of PM2.5 exposure with liver cancer. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0917-5040 1349-9092 |
| Relation: | https://www.jstage.jst.go.jp/article/jea/34/2/34_JE20220262/_pdf; https://doaj.org/toc/0917-5040; https://doaj.org/toc/1349-9092 |
| DOI: | 10.2188/jea.JE20220262 |
| URL الوصول: | https://doaj.org/article/5a4f293689654d4b96a1f817aafead5c |
| رقم الأكسشن: | edsdoj.5a4f293689654d4b96a1f817aafead5c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09175040 13499092 |
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| DOI: | 10.2188/jea.JE20220262 |