دورية أكاديمية
Human Papillomavirus and Risk of Colorectal Cancer: An Analysis of Nationwide Claims Data
| العنوان: | Human Papillomavirus and Risk of Colorectal Cancer: An Analysis of Nationwide Claims Data |
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| المؤلفون: | Chih-Hsiung Hsu, Yu-Jyun Lin, Yong-Chen Chen, I-Lan Liu, San-Lin You, Je-Ming Hu, Tzu-Chiao Lin, Pi-Kai Chang, Chao-Yang Chen, Yu-Ching Chou, Chien-An Sun |
| المصدر: | Medicina, Vol 58, Iss 10, p 1461 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | cohort study, colorectal cancer, human papillomavirus, medical claims dataset, Medicine (General), R5-920 |
| الوصف: | Background and Objectives: Although human papillomavirus (HPV) is a major etiology of cervical and anogenital cancers, whether it is associated with colorectal carcinogenesis is yet undetermined. Materials and Methods: The longitudinal association of HPV infection with colorectal cancer (CRC) was evaluated using 2000–2013 data from a nationwide Taiwanese claims database. In this retrospective cohort study, 358 patients with primary HPV diagnoses (HPV-infected cohort) and 1432 patients without such a diagnosis (HPV-uninfected cohort) were recruited between 2000 and 2006. Both cohorts were followed up to identify CRC incidences from 2006 to 2013. Hazard ratios (HRs) and their 95% confidence intervals (CIs) derived from Cox proportional hazards models were used to estimate the association between HPV and CRC risk. Results: The HPV-infected cohort had a significantly higher cumulative incidence of CRC than the HPV-uninfected cohort. The presence of HPV was associated with an increased risk of CRC (adjusted HR, 1.63; 95% CI, 1.02–3.62). Furthermore, the significant HPV–CRC risk association was evident in both sexes. Conclusions: This population-based cohort study reveals longitudinal evidence that HPV is associated with an increased risk of CRC. Further studies are required to verify the role of HPV in colorectal carcinogenesis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1648-9144 1010-660X |
| Relation: | https://www.mdpi.com/1648-9144/58/10/1461; https://doaj.org/toc/1010-660X; https://doaj.org/toc/1648-9144 |
| DOI: | 10.3390/medicina58101461 |
| URL الوصول: | https://doaj.org/article/c5d41519a33148ae978dfe6971623f1f |
| رقم الأكسشن: | edsdoj.5d41519a33148ae978dfe6971623f1f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16489144 1010660X |
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| DOI: | 10.3390/medicina58101461 |