دورية أكاديمية
Autologous tissue patches acquire vascular identity depending on the environment
| العنوان: | Autologous tissue patches acquire vascular identity depending on the environment |
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| المؤلفون: | Hualong Bai, Jianming Guo, Shirley Liu, Xiangjiang Guo, Haidi Hu, Tun Wang, Toshihiko Isaji, Shun Ono, Bogdan Yatsula, Ying Xing, Alan Dardik |
| المصدر: | Vascular Investigation and Therapy, Vol 1, Iss 1, Pp 14-23 (2018) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | artery, endothelial cell, patch, patch angioplasty, vascular identity, vein, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Background: Vascular identity is genetically determined but can be altered during surgical procedures. Methods: We hypothesized that the environment of the procedure critically alters the identity of autologous tissue patches implanted into the arterial or venous environment. Results: Autologous jugular vein or carotid artery was used as a patch to repair a rat aorta or inferior vena cava. In the aortic environment, patches contained neointimal cells that were CD34/ephrin-B2-dual positive but not CD34/Eph-B4-dual positive; patches expressed ephrin-B2, notch-4, and dll-4 but not Eph-B4 and COUP-TFII. In the venous environment, patches contained neointimal cells that were CD34/Eph-B4-dual positive but not CD34/ephrin-B2-dual positive; patches expressed Eph-B4 and COUP-TFIIbut not ephrin-B2, notch-4, and dll-4. Conclusion: These data show that autologous tissue patches heal by acquisition of the vascular identity determined by the environment into which they are implanted, suggesting some plasticity of adult vascular identity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2589-9686 2589-9481 |
| Relation: | http://www.vitonline.org/article.asp?issn=2589-9686;year=2018;volume=1;issue=1;spage=14;epage=23;aulast=Bai; https://doaj.org/toc/2589-9686; https://doaj.org/toc/2589-9481 |
| DOI: | 10.4103/VIT.VIT_9_18 |
| URL الوصول: | https://doaj.org/article/602d5ff9ac3343b9b94b4da00a8695bd |
| رقم الأكسشن: | edsdoj.602d5ff9ac3343b9b94b4da00a8695bd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25899686 25899481 |
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| DOI: | 10.4103/VIT.VIT_9_18 |