دورية أكاديمية
أعرض في EDS

Soluble CD40 Ligand Levels in Children with Newly Diagnosed Graves’ Disease

التفاصيل البيبلوغرافية
العنوان: Soluble CD40 Ligand Levels in Children with Newly Diagnosed Graves’ Disease
المؤلفون: Kotb Abbass Metwalley, Hekma Saad Farghaly, Duaa Mohammed Raafat, Asmaa Mohammed Ismail, Ghada Mohamed Saied
المصدر: JCRPE, Vol 12, Iss 2, Pp 197-201 (2020)
بيانات النشر: Galenos Yayincilik, 2020.
سنة النشر: 2020
المجموعة: LCC:Pediatrics
LCC:Diseases of the endocrine glands. Clinical endocrinology
مصطلحات موضوعية: graves’ disease, soluble cd40 ligand (scd40l), thyroid hormone, thyroid volume, Pediatrics, RJ1-570, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
الوصف: Objective:Soluble CD40 ligand (sCD40L) is elevated in various autoimmune disorders, which may have diagnostic and therapeutic implications. The aims of the current study were to evaluate serum sCD40L concentrations in children with newly diagnosed Graves’ disease (GD) and to correlate its levels with patients’ clinical and laboratory parameters.Methods:This study included 48 children with newly diagnosed GD and 48 healthy children. Serum thyroid-stimulating hormone (TSH) (TSH, fT4 and fT3), TSH receptor antibodies (TRAbs), high sensitivity C-reactive protein (hsCRP) and sCD40L levels and thyroid volume were measured.Results:Compared to control subjects, children with GD had higher thyroid volume standard deviation scores (SDS) (p=0.001), and higher levels of hsCRP (p=0.001), TRAbs (p=0.001) and sCD40L (p=0.001). Significant correlations were found between sCD40L and age (p=0.01), thyroid volume SDS (p=0.001), hsCRP (p=0.01) and TRAbs (p=0.001). In multivariate analysis, sCD40L concentrations were correlated with TRAbs [odds ratio (OR)=3.1, 95% confidence intervals (CI): 2.2-2.7, p=0.001] and thyroid volume SDS (OR=2.1, 95% CI: 1.2-2.7, p=0.001).Conclusion:This preliminary study has evidence of high concentrations of sCD40L in children with newly diagnosed GD and a correlation between sCD40L and both TRAbs and thyroid volume, which may indicate a biologically active role for sCD40L in the pathogenesis of GD.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1308-5727
1308-5735
Relation: http://www.jcrpe.org/archives/archive-detail/article-preview/soluble-cd40-ligand-levels-in-children-with-newly-/30876; https://doaj.org/toc/1308-5727; https://doaj.org/toc/1308-5735
DOI: 10.4274/jcrpe.galenos.2019.2019.0108
URL الوصول: https://doaj.org/article/60bfd3cf9e7c4101b085615a1cd18e85
رقم الأكسشن: edsdoj.60bfd3cf9e7c4101b085615a1cd18e85
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:13085727
13085735
DOI:10.4274/jcrpe.galenos.2019.2019.0108