دورية أكاديمية
CircRNAs: versatile players and new targets in organ fibrosis
| العنوان: | CircRNAs: versatile players and new targets in organ fibrosis |
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| المؤلفون: | Lei Wei, Limin Liu, Ming Bai, Xiaoxuan Ning, Shiren Sun |
| المصدر: | Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-15 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Cytology |
| مصطلحات موضوعية: | circRNA, Fibrosis, miRNA sponge, Fibroblasts, Exosomal circRNA biomarkers, Therapeutics, Medicine, Cytology, QH573-671 |
| الوصف: | Abstract Organ fibrosis can occur in virtually all major organs with relentlessly progressive and irreversible progress, ultimately resulting in organ dysfunction and potentially death. Unfortunately, current clinical treatments cannot halt or reverse the progression of fibrosis to end-stage organ failure, and thus, advanced antifibrotic therapeutics are urgently needed. In recent years, a growing body of research has revealed that circular RNAs (circRNAs) play pivotal roles in the development and progression of organ fibrosis through highly diverse mechanisms of action. Thus, manipulating circRNAs has emerged as a promising strategy to mitigate fibrosis across different organ types. In this review, we systemically summarize the current state of knowledge about circRNA biological properties and the regulatory mechanisms of circRNAs. A comprehensive overview of major fibrotic signaling pathways and representative circRNAs that are known to modulate fibrotic signals are outlined. Then, we focus on the research progress of the versatile functional roles and underlying molecular mechanisms of circRNAs in various fibrotic diseases in different organs, including the heart, liver, lung, kidney and skin. Finally, we offer a glimpse into the prospects of circRNA-based interference and therapy, as well as their utilization as biomarkers in the diagnosis and prognosis of fibrotic diseases. Video abstract |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1478-811X |
| Relation: | https://doaj.org/toc/1478-811X |
| DOI: | 10.1186/s12964-023-01051-1 |
| URL الوصول: | https://doaj.org/article/da60e73e030f4af8bf51696b0c485130 |
| رقم الأكسشن: | edsdoj.60e73e030f4af8bf51696b0c485130 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1478811X |
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| DOI: | 10.1186/s12964-023-01051-1 |