دورية أكاديمية
Nifuroxazide suppresses PD-L1 expression and enhances the efficacy of radiotherapy in hepatocellular carcinoma
| العنوان: | Nifuroxazide suppresses PD-L1 expression and enhances the efficacy of radiotherapy in hepatocellular carcinoma |
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| المؤلفون: | Tiesuo Zhao, Pengkun Wei, Congli Zhang, Shijie Zhou, Lirui Liang, Shuoshuo Guo, Zhinan Yin, Sichang Cheng, Zerui Gan, Yuanling Xia, Yongxi Zhang, Sheng Guo, Jiateng Zhong, Zishan Yang, Fei Tu, Qianqing Wang, Jin Bai, Feng Ren, Zhiwei Feng, Huijie Jia |
| المصدر: | eLife, Vol 12 (2024) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | hepatocellular carcinoma, PD-L1, radiotherapy, cancer immunotherapy, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Radiation therapy is a primary treatment for hepatocellular carcinoma (HCC), but its effectiveness can be diminished by various factors. The over-expression of PD-L1 has been identified as a critical reason for radiotherapy resistance. Previous studies have demonstrated that nifuroxazide exerts antitumor activity by damaging the Stat3 pathway, but its efficacy against PD-L1 has remained unclear. In this study, we investigated whether nifuroxazide could enhance the efficacy of radiotherapy in HCC by reducing PD-L1 expression. Our results showed that nifuroxazide significantly increased the sensitivity of tumor cells to radiation therapy by inhibiting cell proliferation and migration while increasing apoptosis in vitro. Additionally, nifuroxazide attenuated the up-regulation of PD-L1 expression induced by irradiation, which may be associated with increased degradation of PD-L1 through the ubiquitination-proteasome pathway. Furthermore, nifuroxazide greatly enhanced the efficacy of radiation therapy in H22-bearing mice by inhibiting tumor growth, improving survival, boosting the activation of T lymphocytes, and decelerating the ratios of Treg cells in spleens. Importantly, nifuroxazide limited the increased expression of PD-L1 in tumor tissues induced by radiation therapy. This study confirms, for the first time, that nifuroxazide can augment PD-L1 degradation to improve the efficacy of radiation therapy in HCC-bearing mice. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/90911; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.90911 |
| URL الوصول: | https://doaj.org/article/627ad1e275604b8d8e4eaaef91be7267 |
| رقم الأكسشن: | edsdoj.627ad1e275604b8d8e4eaaef91be7267 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.90911 |