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Enhanced resolution and sensitivity acoustic-resolution photoacoustic microscopy with semi/unsupervised GANs

التفاصيل البيبلوغرافية
العنوان: Enhanced resolution and sensitivity acoustic-resolution photoacoustic microscopy with semi/unsupervised GANs
المؤلفون: Thanh Dat Le, Jung-Joon Min, Changho Lee
المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
بيانات النشر: Nature Portfolio, 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract Acoustic-resolution photoacoustic microscopy (AR-PAM) enables visualization of biological tissues at depths of several millimeters with superior optical absorption contrast. However, the lateral resolution and sensitivity of AR-PAM are generally lower than those of optical-resolution PAM (OR-PAM) owing to the intrinsic physical acoustic focusing mechanism. Here, we demonstrate a computational strategy with two generative adversarial networks (GANs) to perform semi/unsupervised reconstruction with high resolution and sensitivity in AR-PAM by maintaining its imaging capability at enhanced depths. The b-scan PAM images were prepared as paired (for semi-supervised conditional GAN) and unpaired (for unsupervised CycleGAN) groups for label-free reconstructed AR-PAM b-scan image generation and training. The semi/unsupervised GANs successfully improved resolution and sensitivity in a phantom and in vivo mouse ear test with ground truth. We also confirmed that GANs could enhance resolution and sensitivity of deep tissues without the ground truth.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-023-40583-x
URL الوصول: https://doaj.org/article/e65b9152f4a54991b6fd88f98766f7d7
رقم الأكسشن: edsdoj.65b9152f4a54991b6fd88f98766f7d7
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-023-40583-x