دورية أكاديمية
أعرض في EDS

Molecular Networks Involved in the Immune Control of BK Polyomavirus

التفاصيل البيبلوغرافية
العنوان: Molecular Networks Involved in the Immune Control of BK Polyomavirus
المؤلفون: Eva Girmanova, Irena Brabcova, Jiri Klema, Petra Hribova, Mariana Wohlfartova, Jelena Skibova, Ondrej Viklicky
المصدر: Clinical and Developmental Immunology, Vol 2012 (2012)
بيانات النشر: Wiley, 2012.
سنة النشر: 2012
المجموعة: LCC:Immunologic diseases. Allergy
مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607
الوصف: BK polyomavirus infection is the important cause of virus-related nephropathy following kidney transplantation. BK virus reactivates in 30%–80% of kidney transplant recipients resulting in BK virus-related nephropathy in 1%–10% of cases. Currently, the molecular processes associated with asymptomatic infections in transplant patients infected with BK virus remain unclear. In this study we evaluate intrarenal molecular processes during different stages of BKV infection. The gene expression profiles of 90 target genes known to be associated with immune response were evaluated in kidney graft biopsy material using TaqMan low density array. Three patient groups were examined: control patients with no evidence of BK virus reactivation (n=11), infected asymptomatic patients (n=9), and patients with BK virus nephropathy (n=10). Analysis of biopsies from asymptomatic viruria patients resulted in the identification of 5 differentially expressed genes (CD3E, CD68, CCR2, ICAM-1, and SKI) (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1740-2522
1740-2530
Relation: https://doaj.org/toc/1740-2522; https://doaj.org/toc/1740-2530
DOI: 10.1155/2012/972102
URL الوصول: https://doaj.org/article/65ef676ffeb042ab9c5317b24a5439a8
رقم الأكسشن: edsdoj.65ef676ffeb042ab9c5317b24a5439a8
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17402522
17402530
DOI:10.1155/2012/972102