دورية أكاديمية
Transgenic Anopheles mosquitoes expressing human PAI-1 impair malaria transmission
| العنوان: | Transgenic Anopheles mosquitoes expressing human PAI-1 impair malaria transmission |
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| المؤلفون: | Tales V. Pascini, Yeong Je Jeong, Wei Huang, Zarna R. Pala, Juliana M. Sá, Michael B. Wells, Christopher Kizito, Brendan Sweeney, Thiago L. Alves e Silva, Deborah J. Andrew, Marcelo Jacobs-Lorena, Joel Vega-Rodríguez |
| المصدر: | Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022) |
| بيانات النشر: | Nature Portfolio, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Science |
| مصطلحات موضوعية: | Science |
| الوصف: | Plasmodium gametes and sporozoites activate surface-bound plasminogen to plasmin that degrades extracellular matrix barriers, therewith facilitating parasite motility in mosquitoes and mammalian hosts. To control malaria transmission, Pascini et al. generate Anopheles stephensi transgenic mosquitoes constitutively secreting human plasminogen activator inhibitor 1 in midgut and/or saliva which leads to inhibition of plasminogen activation and a reduction in oocyst intensity, infection prevalence, and transmission. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2041-1723 56264305 |
| Relation: | https://doaj.org/toc/2041-1723 |
| DOI: | 10.1038/s41467-022-30606-y |
| URL الوصول: | https://doaj.org/article/6637f4de56264305b96cb1a12269a4bd |
| رقم الأكسشن: | edsdoj.6637f4de56264305b96cb1a12269a4bd |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20411723 56264305 |
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| DOI: | 10.1038/s41467-022-30606-y |