دورية أكاديمية
Alterations of the gut microbiota in the lupus nephritis: a systematic review
| العنوان: | Alterations of the gut microbiota in the lupus nephritis: a systematic review |
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| المؤلفون: | Anjing Wang, Jin Zhao, Yunlong Qin, Yumeng Zhang, Yan Xing, Yuwei Wang, Zixian Yu, Jipeng Yan, Mei Han, Jinguo Yuan, Yueqing Hui, Shuxian Guo, Xiaoxuan Ning, Shiren Sun |
| المصدر: | Renal Failure, Vol 45, Iss 2 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | Gut microbiota, Lupus nephritis, Systemic lupus erythematosus, Systematic review, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | Background Emerging evidence suggests that gut microbiota dysbiosis may play a critical role in the development of lupus nephritis (LN). However, the specific characteristics of the gut microbiota in individuals with LN have not been fully clarified.Methods The PubMed, Web of Science, and Embase databases were systematically searched for clinical and animal studies related to the relationship between LN and gut microbiota from inception until October 1, 2023. A semiquantitative analysis was used to assess the changes in gut microbial profiles.Results A total of 15 clinical studies were selected for analysis, which included 138 LN patients, 441 systemic lupus erythematosus patients, and 1526 healthy controls (HCs). Five different types of LN mouse models were included in 5 animal studies. The alpha diversity was decreased in LN patients compared to HCs. A significant decrease in the Firmicutes/Bacteroidetes (F/B) ratio is considered a hallmark of pathological conditions. Specifically, alterations in the abundance of the phylum Proteobacteria, genera Streptococcus and Lactobacillus, and species Ruminococcus gnavus and Lactobacillus reuteri may play a critical role in the pathogenesis of LN. Remarkably, the gut taxonomic chain Bacteroidetes-Bacteroides-Bacteroides thetaiotaomicron was enriched in LN patients, which could be a crucial characteristic of LN patients. The increased level of interleukin-6, imbalance of regulatory T cells and T helper 17 cells, and decreased level of the intestinal tight junction proteins zonula occludens-1 and claudin-1 also might be related to the pathogenesis of LN.Conclusions Specific changes in the abundance of gut microbiota such as decreased F/B ratio, and the level of inflammatory indicators, and markers of intestinal barrier dysfunction may play a crucial role in the pathogenesis of LN. These factors could be effective diagnostic and potential therapeutic targets for LN. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0886022X 1525-6049 0886-022X |
| Relation: | https://doaj.org/toc/0886-022X; https://doaj.org/toc/1525-6049 |
| DOI: | 10.1080/0886022X.2023.2285877 |
| URL الوصول: | https://doaj.org/article/d665f547ad7140c7827dbd2a2aca79b1 |
| رقم الأكسشن: | edsdoj.665f547ad7140c7827dbd2a2aca79b1 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 0886022X 15256049 |
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| DOI: | 10.1080/0886022X.2023.2285877 |