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The combined effects of simulated microgravity and X-ray radiation on MC3T3-E1 cells and rat femurs

التفاصيل البيبلوغرافية
العنوان: The combined effects of simulated microgravity and X-ray radiation on MC3T3-E1 cells and rat femurs
المؤلفون: Jingjing Dong, Honghui Wang, Gaozhi Li, Ke Wang, Yingjun Tan, Lijun Zhang, Yixuan Wang, Zebing Hu, Xinsheng Cao, Fei Shi, Shu Zhang
المصدر: npj Microgravity, Vol 7, Iss 1, Pp 1-8 (2021)
بيانات النشر: Nature Portfolio, 2021.
سنة النشر: 2021
المجموعة: LCC:Biotechnology
LCC:Physiology
مصطلحات موضوعية: Biotechnology, TP248.13-248.65, Physiology, QP1-981
الوصف: Abstract Microgravity is well-known to induce Osteopenia. However, the combined effects of microgravity and radiation that commonly exist in space have not been broadly elucidated. This research investigates the combined effects on MC3T3-E1 cells and rat femurs. In MC3T3-E1 cells, simulated microgravity and X-ray radiation, alone or combination, show decreased cell activity, increased apoptosis rates by flow cytometric analysis, and decreased Runx2 and increased Caspase-3 mRNA and protein expressions. In rat femurs, simulated microgravity and X-ray radiation, alone or combination, show increased bone loss by micro-CT test and Masson staining, decreased serum BALP levels and Runx2 mRNA expressions, and increased serum CTX-1 levels and Caspase-3 mRNA expressions. The strongest effect is observed in the combined group in MC3T3-E1 cells and rat femurs. These findings suggest that the combination of microgravity and radiation exacerbates the effects of either treatment alone on MC3T3-E1 cells and rat femurs.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2373-8065
Relation: https://doaj.org/toc/2373-8065
DOI: 10.1038/s41526-021-00131-1
URL الوصول: https://doaj.org/article/67244e61898048bebd837b78d2436346
رقم الأكسشن: edsdoj.67244e61898048bebd837b78d2436346
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23738065
DOI:10.1038/s41526-021-00131-1