دورية أكاديمية
DNA-Based Molecular Engineering of the Cell Membrane
| العنوان: | DNA-Based Molecular Engineering of the Cell Membrane |
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| المؤلفون: | Xiaodong Li, Tiantian Wang, Yue Sun, Chang Li, Tianhuan Peng, Liping Qiu |
| المصدر: | Membranes, Vol 12, Iss 2, p 111 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Chemical technology LCC:Chemical engineering |
| مصطلحات موضوعية: | functional nucleic acids, DNA nanotechnology, cell membrane engineering, Chemical technology, TP1-1185, Chemical engineering, TP155-156 |
| الوصف: | The cell membrane serves as a barrier and gatekeeper to regulate the cellular transportation of substances and information. It plays a significant role in protecting the cell from the extracellular environment, maintaining intracellular homeostasis, and regulating cellular function and behaviors. The capability to engineer the cell membrane with functional modules that enable dynamic monitoring and manipulating the cell-surface microenvironment would be critical for studying molecular mechanisms underlying various biological processes. To meet this goal, DNA, with intrinsic advantages of high versatility, programmability, and biocompatibility, has gained intense attention as a molecular tool for cell-surface engineering. The past three decades have witnessed the rapid advances of diverse nucleic acid materials, including functional nucleic acids (FNAs), dynamic DNA circuits, and exquisite DNA nanostructures. In this mini review, we have summarized the recent progress of DNA technology for cell membrane engineering, particularly focused on their applications for molecular sensing and imaging, precise cell identification, receptor activity regulation, and artificial membrane structures. Furthermore, we discussed the challenge and outlook on using nucleic acid materials in this specific research area. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2077-0375 65323874 |
| Relation: | https://www.mdpi.com/2077-0375/12/2/111; https://doaj.org/toc/2077-0375 |
| DOI: | 10.3390/membranes12020111 |
| URL الوصول: | https://doaj.org/article/67aac65323874d2f98e5c0d8cdd01f30 |
| رقم الأكسشن: | edsdoj.67aac65323874d2f98e5c0d8cdd01f30 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20770375 65323874 |
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| DOI: | 10.3390/membranes12020111 |