دورية أكاديمية
Anti-viral efficacy of a next-generation CD4-binding site bNAb in SHIV-infected animals in the absence of anti-drug antibody responses
| العنوان: | Anti-viral efficacy of a next-generation CD4-binding site bNAb in SHIV-infected animals in the absence of anti-drug antibody responses |
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| المؤلفون: | Sarah E. Lovelace, Sabrina Helmold Hait, Eun Sung Yang, Madison L. Fox, Cuiping Liu, Misook Choe, Xuejun Chen, Elizabeth McCarthy, John-Paul Todd, Ruth A. Woodward, Richard A. Koup, John R. Mascola, Amarendra Pegu |
| المصدر: | iScience, Vol 25, Iss 10, Pp 105067- (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Science |
| مصطلحات موضوعية: | Immunology, Virology, Drugs, Science |
| الوصف: | Summary: Broadly neutralizing antibodies (bNAbs) against HIV-1 are promising immunotherapeutic agents for treatment of HIV-1 infection. bNAbs can be administered to SHIV-infected rhesus macaques to assess their anti-viral efficacy; however, their delivery into macaques often leads to rapid formation of anti-drug antibody (ADA) responses limiting such assessment. Here, we depleted B cells in five SHIV-infected rhesus macaques by pretreatment with a depleting anti-CD20 antibody prior to bNAb infusions to reduce ADA. Peripheral B cells were depleted following anti-CD20 infusions and remained depleted for at least 9 weeks after the 1st anti-CD20 infusion. Plasma viremia dropped by more than 100-fold in viremic animals after the initial bNAb treatment. No significant humoral ADA responses were detected for as long as B cells remained depleted. Our results indicate that transient B cell depletion successfully inhibited emergence of ADA and improved the assessment of anti-viral efficacy of a bNAb in a SHIV-infected rhesus macaque model. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2589-0042 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2589004222013396; https://doaj.org/toc/2589-0042 |
| DOI: | 10.1016/j.isci.2022.105067 |
| URL الوصول: | https://doaj.org/article/e67fba8088444e1197904baa6ce1582e |
| رقم الأكسشن: | edsdoj.67fba8088444e1197904baa6ce1582e |
| قاعدة البيانات: | Directory of Open Access Journals |
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