دورية أكاديمية
Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons
| العنوان: | Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons |
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| المؤلفون: | Songshan Li, Qinghai He, Hao Wang, Xuming Tang, Kam Wing Ho, Xin Gao, Qian Zhang, Yang Shen, Annie Cheung, Francis Wong, Yung Hou Wong, Nancy Y. Ip, Liwen Jiang, Wing Ho Yung, Kai Liu |
| المصدر: | Neurobiology of Disease, Vol 73, Iss , Pp 366-376 (2015) |
| بيانات النشر: | Elsevier, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: | Axon regeneration and rewiring, Intrinsic mechanisms, Pre-chiasm lesion, Retinal ganglion cells, Suprachiasmatic nucleus, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | Despite advances in promoting axonal regeneration after adult central nervous system injury, elicitation of a large number of lesion-passing axons reform active synaptic connections with natural target neurons remains limited. By deleting both Pten and Socs3 in retinal ganglion cells, we report that optic nerve axons after prechiasm lesion robustly reinnervate the hypothalamus, form new synapses with neurons in the suprachiasmatic nucleus (SCN), and re-integrate with the existing circuitry. Photic or electric stimulation of the retinal axons induces neuronal response in SCN. However both the innervation pattern and evoked responses are not completely restored by the regenerating axons, suggesting that combining with other strategies is necessary to overcome the defective rewiring. Our results support that boosting the intrinsic growth capacity in injured neurons promotes axonal reinnervation and rewiring. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1095-953X 68286708 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0969996114002927; https://doaj.org/toc/1095-953X |
| DOI: | 10.1016/j.nbd.2014.09.019 |
| URL الوصول: | https://doaj.org/article/68286708873b409894b25f4e6d9722d8 |
| رقم الأكسشن: | edsdoj.68286708873b409894b25f4e6d9722d8 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 1095953X 68286708 |
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| DOI: | 10.1016/j.nbd.2014.09.019 |