دورية أكاديمية
TPGS/hyaluronic acid dual-functionalized PLGA nanoparticles delivered through dissolving microneedles for markedly improved chemo-photothermal combined therapy of superficial tumor
العنوان: | TPGS/hyaluronic acid dual-functionalized PLGA nanoparticles delivered through dissolving microneedles for markedly improved chemo-photothermal combined therapy of superficial tumor |
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المؤلفون: | Tingting Peng, Yao Huang, Xiaoqian Feng, Chune Zhu, Shi Yin, Xinyi Wang, Xuequn Bai, Xin Pan, Chuanbin Wu |
المصدر: | Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3297-3309 (2021) |
بيانات النشر: | Elsevier, 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Therapeutics. Pharmacology |
مصطلحات موضوعية: | Functionalized PLGA nanoparticles, TPGS, Hyaluronic acid, Chemotherapy, Photothermal therapy, Dissolving microneedles, Therapeutics. Pharmacology, RM1-950 |
الوصف: | Nanoparticles (NPs) have shown potential in cancer therapy, while a single administration conferring a satisfactory outcome is still unavailable. To address this issue, the dissolving microneedles (DMNs) were developed to locally deliver functionalized NPs with combined chemotherapy and photothermal therapy (PTT). α-Tocopheryl polyethylene glycol succinate (TPGS)/hyaluronic acid (HA) dual-functionalized PLGA NPs (HD10 NPs) were fabricated to co-load paclitaxel and indocyanine green. HD10 NPs significantly enhanced the cytotoxicity of low-dose paclitaxel because of active and mitochondrial targeting by HA and TPGS, respectively. PTT could further sensitize tumor cells toward chemotherapy by promoting apoptosis into the advanced period, highly activating caspase 3 enzyme, and significantly reducing the expression of survivin and MMP-9 proteins. Further, the anti-tumor effects of HD10 NPs delivered through different administration routes were conducted on the 4T1 tumor-bearing mice. After a single administration, HD10 NPs delivered with DMNs showed the best anti-tumor effect when giving chemotherapy alone. As expected, the anti-tumor effect was profoundly enhanced after combined therapy, and complete tumor ablation was achieved in the mice treated with DMNs and intra-tumor injection. Moreover, DMNs showed better safety due to moderate hyperthermia. Therefore, the DMNs along with combined chemo-photothermal therapy provide a viable treatment option for superficial tumors. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2211-3835 |
Relation: | http://www.sciencedirect.com/science/article/pii/S2211383520308030; https://doaj.org/toc/2211-3835 |
DOI: | 10.1016/j.apsb.2020.11.013 |
URL الوصول: | https://doaj.org/article/68fdfeabf622444980f6e859ad9eca55 |
رقم الأكسشن: | edsdoj.68fdfeabf622444980f6e859ad9eca55 |
قاعدة البيانات: | Directory of Open Access Journals |
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