دورية أكاديمية
Polymorphisms in the Promoter Region of the Chinese Bovine Gene
| العنوان: | Polymorphisms in the Promoter Region of the Chinese Bovine Gene |
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| المؤلفون: | M. J. Li, M. Liu, D. Liu, X. Y. Lan, C. Z. Lei, D. Y. Yang, H. Chen |
| المصدر: | Asian-Australasian Journal of Animal Sciences, Vol 26, Iss 4, Pp 483-487 (2013) |
| بيانات النشر: | Asian-Australasian Association of Animal Production Societies, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Animal culture LCC:Animal biochemistry |
| مصطلحات موضوعية: | Bovine, Gene, Promoter Region, Polymorphisms, Animal culture, SF1-1100, Animal biochemistry, QP501-801 |
| الوصف: | The peroxisome proliferator-activated receptor gamma coactivator-1 alpha protein, encoded by the PPARGC1A gene, plays an important role in energy homeostasis. The genetic variations within the PPARGC1A gene promoter region were scanned in 808 Chinese native bovines belonging to three cattle breeds and yaks. A total of 6 SNPs and one 4 bp insertion variation in the promoter region of the bovine PPARGC1A gene were identified: SNP -259 T>A, -301_-298insCTTT, -915 A>G, -1175 T>G, -1590 C>T, -1665 C>T and -1690 G>A, which are in the binding sites of some important transcription factors: sex-determining region Y (SRY), myeloid-specific zinc finger-1 (MZF-1) and octamer factor 1(Oct-1). It is expected that these polymorphisms may regulate PPARGC1A gene transcription and might have consequences at a regulatory level. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1011-2367 1976-5517 |
| Relation: | http://www.ajas.info/upload/pdf/ajas-26-4-483-5.pdf; https://doaj.org/toc/1011-2367; https://doaj.org/toc/1976-5517 |
| DOI: | 10.5713/ajas.2012.12554 |
| URL الوصول: | https://doaj.org/article/69a8fb3da2f042b8be539e11d74183d2 |
| رقم الأكسشن: | edsdoj.69a8fb3da2f042b8be539e11d74183d2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10112367 19765517 |
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| DOI: | 10.5713/ajas.2012.12554 |