دورية أكاديمية
أعرض في EDS

Impacts of WNT1-inducible signaling pathway protein 1 polymorphism on hepatocellular carcinoma development.

التفاصيل البيبلوغرافية
العنوان: Impacts of WNT1-inducible signaling pathway protein 1 polymorphism on hepatocellular carcinoma development.
المؤلفون: Chih-Tien Chen, Hsiang-Lin Lee, Hui-Ling Chiou, Chia-Hsuan Chou, Po-Hui Wang, Shun-Fa Yang, Ying-Erh Chou
المصدر: PLoS ONE, Vol 13, Iss 6, p e0198967 (2018)
بيانات النشر: Public Library of Science (PLoS), 2018.
سنة النشر: 2018
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: BACKGROUND:WNT1-inducible signaling pathway protein 1 (WISP1) is a member of CCN protein family and a downstream target of β-catenin. Aberrant WISP1 expression is associated with carcinogenesis. In the current study, we focused on examining WISP1 single nucleotide polymorphisms (SNPs) to elucidate hepatocellular carcinoma (HCC) clinicopathologic characteristics. METHODOLOGY/PRINCIPAL FINDINGS:The WISP1 SNPs rs2977530, rs2977537, rs2929973, rs2929970, rs62514004, and rs16893344 were analyzed by real-time polymerase chain reaction in 332 patients with HCC and 664 cancer-free controls. RESULTS:The patients with higher frequencies of WISP1 rs62514004 (AG + GG) and rs16893344 (CT + TT) variants revealed a lower risk to reach a later clinical stage compared with their wild-type carriers. Furthermore, individuals who carried WISP1 rs62514004 and rs16893344 haplotype G-T showed a greater synergistic effect combined with alcohol drinking on HCC development (AOR = 26.590, 95% CI = 9.780-72.295). CONCLUSIONS:Our results demonstrated that the HCC patients with WISP1 SNPs are associated with HCC development, and WISP1 SNPs may serve as markers or therapeutic targets for HCC.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC5995385?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0198967
URL الوصول: https://doaj.org/article/69b9bcc6e0104a54ab0dcaff8971d07f
رقم الأكسشن: edsdoj.69b9bcc6e0104a54ab0dcaff8971d07f
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0198967