دورية أكاديمية
Gender as a factor affecting NK cell activity in patients successfully treated for chronic hepatitis C with direct-acting antivirals
العنوان: | Gender as a factor affecting NK cell activity in patients successfully treated for chronic hepatitis C with direct-acting antivirals |
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المؤلفون: | Agata Zientarska, Justyna Mikuła-Pietrasik, Mariusz Kaczmarek, Aleksandra Witkowska, Błażej Rozpłochowski, Arleta Kowala-Piaskowska, Krzysztof Książek, Jan Żeromski, Iwona Mozer-Lisewska |
المصدر: | Central European Journal of Immunology, Vol 46, Iss 4, Pp 481-491 (2021) |
بيانات النشر: | Termedia Publishing House, 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Medicine |
مصطلحات موضوعية: | hcv, gender, nk cells, direct-acting antivirals., Medicine |
الوصف: | Chronic hepatitis C (CHC) affects the activity of natural killer (NK) cells, but successful interferon- free treatment partially restores it. The goal of this study was to assess whether gender influences NK functionality. We examined 21 post-menopausal women and 24 men with CHC who were treated with direct-acting antivirals (DAA) and 33 healthy volunteers. Using flow cytometry, we analysed KIR2DS4, NKG2D, NKp30, KIR2DL2/DL3, NKG2A and TRAIL on the surface of NK cells. Intracellular granzyme B was also assessed and serum CXCL10 was quantified via ELISA. Overall, patients with CHC had higher expression of KIR2DS4, NKG2A, and NKp30 relative to the control group. Further, CHC patients had a lower percentage of NK cells among lymphocytes relative to the control group. After treatment, KIR2DS4, KIR2DL2/DL, NKG2A, TRAIL and NKp30 on NK cells were decreased whilst the percentage of NK cells and the expression of granzyme B and NKG2D increased. Prior to treatment, serum CXCL10 was elevated, but it was inhibited post-treatment. We observed gender-specific differences in the expression of KIR2DL2/DL3 (higher in women) and NKp30 (elevated in men) compared to CHC/control groups. After treatment, KIR2DL2/DL3, NKp30 and CXCL10 dropped only in the female group while granzyme B increased in the male group. In conclusion, the response of NK cells among men and women of post-menopausal ages with CHC differs. Our research may lead to more studies on the different nature of female and male immune systems in the context of HCV infection and treatment. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1426-3912 1644-4124 |
Relation: | https://www.termedia.pl/Gender-as-a-factor-affecting-NK-cell-activity-in-patients-successfully-treated-for-chronic-hepatitis-C-with-direct-acting-antivirals,10,45402,1,1.html; https://doaj.org/toc/1426-3912; https://doaj.org/toc/1644-4124 |
DOI: | 10.5114/ceji.2021.109846 |
URL الوصول: | https://doaj.org/article/6b7c7e6139c147018b8ac28db6503b9f |
رقم الأكسشن: | edsdoj.6b7c7e6139c147018b8ac28db6503b9f |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14263912 16444124 |
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DOI: | 10.5114/ceji.2021.109846 |