دورية أكاديمية

Gender as a factor affecting NK cell activity in patients successfully treated for chronic hepatitis C with direct-acting antivirals

التفاصيل البيبلوغرافية
العنوان: Gender as a factor affecting NK cell activity in patients successfully treated for chronic hepatitis C with direct-acting antivirals
المؤلفون: Agata Zientarska, Justyna Mikuła-Pietrasik, Mariusz Kaczmarek, Aleksandra Witkowska, Błażej Rozpłochowski, Arleta Kowala-Piaskowska, Krzysztof Książek, Jan Żeromski, Iwona Mozer-Lisewska
المصدر: Central European Journal of Immunology, Vol 46, Iss 4, Pp 481-491 (2021)
بيانات النشر: Termedia Publishing House, 2021.
سنة النشر: 2021
المجموعة: LCC:Medicine
مصطلحات موضوعية: hcv, gender, nk cells, direct-acting antivirals., Medicine
الوصف: Chronic hepatitis C (CHC) affects the activity of natural killer (NK) cells, but successful interferon- free treatment partially restores it. The goal of this study was to assess whether gender influences NK functionality. We examined 21 post-menopausal women and 24 men with CHC who were treated with direct-acting antivirals (DAA) and 33 healthy volunteers. Using flow cytometry, we analysed KIR2DS4, NKG2D, NKp30, KIR2DL2/DL3, NKG2A and TRAIL on the surface of NK cells. Intracellular granzyme B was also assessed and serum CXCL10 was quantified via ELISA. Overall, patients with CHC had higher expression of KIR2DS4, NKG2A, and NKp30 relative to the control group. Further, CHC patients had a lower percentage of NK cells among lymphocytes relative to the control group. After treatment, KIR2DS4, KIR2DL2/DL, NKG2A, TRAIL and NKp30 on NK cells were decreased whilst the percentage of NK cells and the expression of granzyme B and NKG2D increased. Prior to treatment, serum CXCL10 was elevated, but it was inhibited post-treatment. We observed gender-specific differences in the expression of KIR2DL2/DL3 (higher in women) and NKp30 (elevated in men) compared to CHC/control groups. After treatment, KIR2DL2/DL3, NKp30 and CXCL10 dropped only in the female group while granzyme B increased in the male group. In conclusion, the response of NK cells among men and women of post-menopausal ages with CHC differs. Our research may lead to more studies on the different nature of female and male immune systems in the context of HCV infection and treatment.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1426-3912
1644-4124
Relation: https://www.termedia.pl/Gender-as-a-factor-affecting-NK-cell-activity-in-patients-successfully-treated-for-chronic-hepatitis-C-with-direct-acting-antivirals,10,45402,1,1.html; https://doaj.org/toc/1426-3912; https://doaj.org/toc/1644-4124
DOI: 10.5114/ceji.2021.109846
URL الوصول: https://doaj.org/article/6b7c7e6139c147018b8ac28db6503b9f
رقم الأكسشن: edsdoj.6b7c7e6139c147018b8ac28db6503b9f
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14263912
16444124
DOI:10.5114/ceji.2021.109846