دورية أكاديمية
Clomiphene citrate, metformin or a combination of both as the first line ovulation induction drug for Asian Indian women with polycystic ovarian syndrome: A randomized controlled trial
| العنوان: | Clomiphene citrate, metformin or a combination of both as the first line ovulation induction drug for Asian Indian women with polycystic ovarian syndrome: A randomized controlled trial |
|---|---|
| المؤلفون: | Sujata Kar, Smriti Sanchita |
| المصدر: | Journal of Human Reproductive Sciences, Vol 8, Iss 4, Pp 197-201 (2015) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Gynecology and obstetrics |
| مصطلحات موضوعية: | Clomiphene citrate, metformin, ovulation induction, polycystic ovary syndrome, pregnancy rate, Gynecology and obstetrics, RG1-991 |
| الوصف: | Aim: To compare clomiphene citrate (CC), metformin or the combination of CC and metformin as the first line ovulation induction drug in Asian Indian women with polycystic ovary syndrome (PCOS). Methods: One hundred and five newly diagnosed, treatment naive PCOS women were recruited. They were randomized into any of the three groups: Group I (CC 50-150 mg/day), Group II (metformin 1700 mg/day), and Group III (CC + metformin in similar dosage to Groups I and II). Patients underwent follicular monitoring and advice on timed intercourse. The study period was 6 months, or till pregnant, or till CC resistant. Primary outcome studied was live birth rate (LBR). Secondary outcomes were ovulation rate, pregnancy rate, and early pregnancy loss rate. Results: There was no significant difference among the groups in baseline characteristics and biochemical parameters. LBR was 41.6%, 37.5%, and 28.1%, respectively in Groups III, II, and I. Group III (CC + metformin) had the highest ovulation (83.3%), pregnancy (50%), and LBRs (41.6%). Group II (metformin) was as good as Group I (CC) in all the outcomes. CC + metformin (Group III) had statistically significantly higher ovulation rate as compared to CC alone (Group I) (P = 0.03; odds ratio: 95% confidence interval: 3.888 [1.08-13.997]). Conclusion: Thus, our study shows that metformin was as good as CC in terms of "LBR" and the combination of CC and metformin gave the highest ovulation and LBR. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0974-1208 1998-4766 |
| Relation: | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2015;volume=8;issue=4;spage=197;epage=201;aulast=Kar; https://doaj.org/toc/0974-1208; https://doaj.org/toc/1998-4766 |
| DOI: | 10.4103/0974-1208.170373 |
| URL الوصول: | https://doaj.org/article/6b8b42d9f6ee46ee859c304814a1cbbd |
| رقم الأكسشن: | edsdoj.6b8b42d9f6ee46ee859c304814a1cbbd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09741208 19984766 |
|---|---|
| DOI: | 10.4103/0974-1208.170373 |