دورية أكاديمية
أعرض في EDS

Lycopene Inhibits Propagation of Chlamydia Infection

التفاصيل البيبلوغرافية
العنوان: Lycopene Inhibits Propagation of Chlamydia Infection
المؤلفون: Naylia A. Zigangirova, Elena Y. Morgunova, Elena D. Fedina, Natalia V. Shevyagina, Tatiana G. Borovaya, Vladimir G. Zhukhovitsky, Nigel H. Kyle, Ivan M. Petyaev
المصدر: Scientifica, Vol 2017 (2017)
بيانات النشر: Wiley, 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Chlamydiaceae is a family of obligate intracellular pathogenic bacteria with similar developmental cycles and cell biology responsible for a wide range of diseases in different hosts including genital and eye inflammatory diseases, arthritis, and inflammatory diseases of the respiratory and cardiovascular systems. In the present paper, we report that lycopene, one of the main dietary carotenoids, which is present in tomato and some other fruits, has a strong inhibitory effect on C. trachomatis and C. pneumoniae infections in alveolar macrophages. This finding was documented by both immunofluorescence analysis and electron microscopy. It was noted that lycopene treatment inhibited intracellular phase of the chlamydial developmental cycle and resulted in a significant loss of infectious progeny. The antichlamydial effect of lycopene was also confirmed in a clinical setting. There was a significant reduction of IgG antibodies against C. pneumoniae in the serum of volunteers treated for a month with oral ingestion of 7 mg of lycopene. Additional studies are needed to further explore the antichlamydial activity of lycopene and its possible effect on C. pneumoniae in relation to antichlamydial activity of lycopene to mechanisms of atherosclerosis.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2090-908X
Relation: https://doaj.org/toc/2090-908X
DOI: 10.1155/2017/1478625
URL الوصول: https://doaj.org/article/c6c72a20325f460680a7c535576277f9
رقم الأكسشن: edsdoj.6c72a20325f460680a7c535576277f9
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2090908X
DOI:10.1155/2017/1478625