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Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children

التفاصيل البيبلوغرافية
العنوان: Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children
المؤلفون: Yang Zhou, Li-Wen Hu, Zhengmin (Min) Qian, Sarah Dee Geiger, Katelyn L. Parrish, Shyamali C. Dharmage, Brittany Campbell, Marjut Roponen, Pasi Jalava, Maija-Riitta Hirvonen, Joachim Heinrich, Xiao-Wen Zeng, Bo-Yi Yang, Xiao-Di Qin, Yungling Leo Lee, Guang-Hui Dong
المصدر: Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
بيانات النشر: Nature Portfolio, 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract To evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009–2010. The interaction between PFASs and reproductive hormones on asthma was analyzed with a two-level binary logistic regression model. The results showed that, among asthmatics, PFASs were positively associated with estradiol levels and negatively associated with testosterone levels. However, only significant association was identified for PFNA and estradiol in control group. After controlling for hormone levels, associations between PFAS exposure and asthma were consistently stronger among children with higher than lower estradiol, with odds ratios (OR) for asthma ranging from 1.25 for PFOS (95% Confidence Interval [CI]: 0.90, 1.72) to 4.01 for PFDA (95% CI: 1.46, 11.06) among boys and 1.25 for PFOS (95% CI: 0.84, 1.86) to 4.16 for PFNA (95% CI: 1.36, 12.73) among girls. Notably, the interactions between estradiol and PFASs were significant for PFOS (p = 0.026) and PFNA (p = 0.043) among girls. However, testosterone significantly attenuated the association between PFOS and asthma across sex. In conclusions, our findings suggested that reproductive hormones amplify the association between PFASs and asthma among adolescents.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-017-01140-5
URL الوصول: https://doaj.org/article/cdc6d93a68af4031a68e659b458e9448
رقم الأكسشن: edsdoj.6d93a68af4031a68e659b458e9448
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-017-01140-5