دورية أكاديمية
The emerging role of exosomes in the development of testicular
| العنوان: | The emerging role of exosomes in the development of testicular |
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| المؤلفون: | Chun-Yang Li, Song-Po Liu, Xiao-Fang Dai, Dong-Feng Lan, Tao Song, Xian-Yao Wang, Qing-Hong Kong, Jun Tan, Ji-Dong Zhang |
| المصدر: | Asian Journal of Andrology, Vol 25, Iss 5, Pp 547-555 (2023) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | exosomes, mirna, sertoli cells, sperm, testis, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | The mechanisms of testicular development in mammals are complex. Testis is an organ that produces sperm and secretes androgens. It is rich in exosomes and cytokines that mediate signal transduction between tubule germ cells and distal cells, promoting testicular development and spermatogenesis. Exosomes are nanoscale extracellular vesicles that transmit information between cells. By transmitting information, exosomes play an important role in male infertility diseases such as azoospermia, varicocele, and testicular torsion. However, due to the wide range of sources of exosomes, extraction methods are numerous and complex. Therefore, there are many difficulties in studying the mechanisms of exosomal effects on normal development and male infertility. Therefore, in this review, first, we introduce the formation of exosomes and methods for culturing testis and sperm. Then, we introduce the effects of exosomes on different stages of testicular development. Finally, we summarize the prospects and shortcomings of exosomes when used in clinical applications. We lay the theoretical foundation for the mechanism of the influence of exosomes on normal development and male infertility. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1008-682X 1745-7262 |
| Relation: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2023;volume=25;issue=5;spage=547;epage=555;aulast=Li; https://doaj.org/toc/1008-682X; https://doaj.org/toc/1745-7262 |
| DOI: | 10.4103/aja2022126 |
| URL الوصول: | https://doaj.org/article/6dcf13577e9149c58c78747c5abcdd19 |
| رقم الأكسشن: | edsdoj.6dcf13577e9149c58c78747c5abcdd19 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1008682X 17457262 |
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| DOI: | 10.4103/aja2022126 |