دورية أكاديمية
A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in mice
| العنوان: | A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in mice |
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| المؤلفون: | Hyuk-Kwon Kwon, Mahesh Chandra Patra, Hyeon-Jun Shin, Xiangai Gui, Asma Achek, Suresh Panneerselvam, Dong-Jin Kim, Suk-Jong Song, Riwon Hong, Kyoung Soo Kim, Yang Gyun Kim, Francis Y. Lee, Dae-Hyun Hahm, Sang Ho Lee, Sangdun Choi |
| المصدر: | Experimental and Molecular Medicine, Vol 51, Iss 4, Pp 1-19 (2019) |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine LCC:Biochemistry |
| مصطلحات موضوعية: | Medicine, Biochemistry, QD415-436 |
| الوصف: | Inflammation: A decoy peptide treats arthritis and sepsis in mice A newly discovered peptide drug that disrupts signaling through a critical immune pathway could offer a new treatment for inflammatory diseases. Sangdun Choi from Ajou University in Suwon, South Korea, and colleagues designed the drug to look similar to—and thus act as kind of decoy for—a protein that regulates signaling through Toll-like receptors (TLRs), proteins found on immune cells that initiate responses to pathogens and also play a role in autoimmunity. In mouse and human cells, the drug inhibited multiple TLR signaling pathways, including a pathway that normally activates a multiprotein complex implicated in a variety of inflammatory diseases. In mouse models of rheumatoid arthritis and sepsis, the drug limited the release of proinflammatory molecules in the blood and reduced disease symptoms. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1226-3613 2092-6413 |
| Relation: | https://doaj.org/toc/1226-3613; https://doaj.org/toc/2092-6413 |
| DOI: | 10.1038/s12276-019-0244-0 |
| URL الوصول: | https://doaj.org/article/d6e0d5885d2f46d4af80b5803f5e237b |
| رقم الأكسشن: | edsdoj.6e0d5885d2f46d4af80b5803f5e237b |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 12263613 20926413 |
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| DOI: | 10.1038/s12276-019-0244-0 |