دورية أكاديمية
Clinical management of oligometastatic cancer: Applying multidisciplinary tumor board recommendations in practice
| العنوان: | Clinical management of oligometastatic cancer: Applying multidisciplinary tumor board recommendations in practice |
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| المؤلفون: | Sebastian M. Christ, Minsu Breitenstein, Philip Heesen, Brandon Turner, Urs J. Muehlematter, Kaspar Pohl, Jonas Willmann, Alexander Maurer, Sukhdeep K. Nagpal, Maiwand Ahmadsei, Eugenia Badra Vlaskou, Esmée L. Looman, Astrid E. Heusel, Michael Mayinger, Panagiotis Balermpas, Andreas Wicki, Nicolaus Andratschke, Tracy Balboni, Mai Anh Huynh, Martin Huellner, Matthias Guckenberger |
| المصدر: | Clinical and Translational Radiation Oncology, Vol 48, Iss , Pp 100838- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Oligometastasis, Multidisciplinary tumor board, Therapeutic management, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Aims: Multidisciplinary tumor boards (MDTs) are an integral part of ensuring high-quality, evidence-based and personalized cancer care. In this study, we aimed to evaluate the adherence to and implementation of MDT recommendations in patients with oligometastatic disease (OMD). Methods: We screened all oncologic positron emission tomography (PET) scans conducted at a single comprehensive cancer center in 2020. Patients were included if they had evidence of imaging-based OMD from a solid organ malignancy on the index scans, had their OMD case discussed at an MDT, and were treated and followed up at the same center. A switch away from the MDT-recommended treatment modalities was classified as a major deviation; non-MDT-mandated adjustments to a recommended treatment modality were coded as minor deviation. Clinical data was obtained via chart review; statistical calculations were computed using the R software. Results: After review of PET and/or concurrent brain scans, 787 cases of OMD were identified. Thereof, 347 (44.1 %) cases were discussed at MDT, of which 331 (42.1 %) were therapeutically managed and subsequently followed. The three most commonly recommended therapies were systemic therapy (35.6 %), multimodality treatment including definitive local therapy (17.8 %), and radiotherapy (13.9 %). A major deviation was recorded in 16.3 % of cases (most commonly: none of the MDT-recommended treatment modalities were performed: 19 (35.2 %); not all MDT-planned treatment modalities were performed: 12 (22.2 %); and additional treatment modality was performed: 11 (20.3 %). A minor deviation was found in 1.5 % of cases. On multivariable regression, number of distant metastases (n > 1) was associated with a major deviation (OR: 1.85; 95 % CI, 1.0–3.52). Major deviations were associated with a significantly worse OS (p = 0.0034). Conclusions: Adherence to and implementation of MDT recommendations in OMD patients was generally high (83.7%). Major deviations might be further reduced by more careful and elaborate discussions of OMD patient characteristics s and patient preferences. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-6308 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405630824001150; https://doaj.org/toc/2405-6308 |
| DOI: | 10.1016/j.ctro.2024.100838 |
| URL الوصول: | https://doaj.org/article/71afaa6e28d24a95b3a352ae6abdb40c |
| رقم الأكسشن: | edsdoj.71afaa6e28d24a95b3a352ae6abdb40c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24056308 |
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| DOI: | 10.1016/j.ctro.2024.100838 |