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SPRY4-IT1 promotes survival of colorectal cancer cells through regulating PDK1-mediated glycolysis

التفاصيل البيبلوغرافية
العنوان: SPRY4-IT1 promotes survival of colorectal cancer cells through regulating PDK1-mediated glycolysis
المؤلفون: Shengyuan Liu, Feng Huang, Qing Ye, Yangming Li, Jinhu Chen, Hong Huang
المصدر: Animal Cells and Systems, Vol 24, Iss 4, Pp 220-227 (2020)
بيانات النشر: Taylor & Francis Group, 2020.
سنة النشر: 2020
المجموعة: LCC:Medicine (General)
LCC:Biology (General)
مصطلحات موضوعية: spry4-it1, colorectal cancer (crc), proliferation, glycolysis, molecular target, Medicine (General), R5-920, Biology (General), QH301-705.5
الوصف: Colorectal cancer (CRC) becomes the third leading cause of cancer-related deaths worldwide recently. The prognosis of CRC is still poor in decades, and targeted therapy is still a potential effective treatment. Long non-coding RNAs (lncRNAs) could regulate series of cellular functions and developmental processes. LncRNA-SPRY4-IT1 (GenBank ID AK024556) is derived from an intron of the SPRY4 gene, which was highly expressed in melanoma cells and affected the progression of multiple types of cancers. However, the mechanism of SPRY4-IT1 in CRC progression remains unclear. Herein, we found the high level of SPRY4-IT1 in human colorectal cancer (CRC) tissues and cells, and correlated with patients’ prognosis. We further noticed that SPRY4-IT1 regulated CRC cell growth and glycolysis, and promoting PDK1 expression. Our data further confirmed that SPRY4-IT1 regulated CRC progression targeting PDK1. We therefore thought SPRY4-IT1 could serve as a promising molecular target for the treatment of CRC.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1976-8354
2151-2485
19768354
Relation: https://doaj.org/toc/1976-8354; https://doaj.org/toc/2151-2485
DOI: 10.1080/19768354.2020.1784274
URL الوصول: https://doaj.org/article/71f2656ed26f4bfb820d4d870959e508
رقم الأكسشن: edsdoj.71f2656ed26f4bfb820d4d870959e508
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19768354
21512485
DOI:10.1080/19768354.2020.1784274