Objective To explore the role of CD200 in Ewing's sarcoma and its possible pathological mechanisms, and to search for potential drugs that can improve the survival prognosis of Ewing's sarcoma patients. Methods The RNA seq and clinical data of Ewing's sarcoma patients were obtained from the International Cancer Genome Consortium database. The survival analysis was used to explore the impact of CD200 on the survival prognosis of Ewing's sarcoma patients. The gene set enrichment analysis (GSEA) and Lincx analysis were carried out to find the molecular mechanism of CD200 promoting the malignant process of Ewing's sarcoma and the anti-Ewing's sarcoma drugs that may target CD200. The expression level of CD200 was verified by RT qPCR. Results CD200 was significantly overexpressed in Ewing's sarcoma cells (P
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