دورية أكاديمية
The association between sleep quality and accelerated epigenetic aging with metabolic syndrome in Korean adults
| العنوان: | The association between sleep quality and accelerated epigenetic aging with metabolic syndrome in Korean adults |
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| المؤلفون: | Ho-Sun Lee, Boram Kim, Taesung Park |
| المصدر: | Clinical Epigenetics, Vol 16, Iss 1, Pp 1-9 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Genetics |
| مصطلحات موضوعية: | PSQI, Poor sleepers, Epigenetic age acceleration, DunedinPACE, Metabolic syndrome, Medicine, Genetics, QH426-470 |
| الوصف: | Abstract Background Healthy sleep is vital for maintaining optimal mental and physical health. Accumulating evidence suggests that sleep loss and disturbances play a significant role in the biological aging process, early onset of disease, and reduced lifespan. While numerous studies have explored the association between biological aging and its drivers, only a few studies have examined its relationship with sleep quality. In this study, we investigated the associations between sleep quality and epigenetic age acceleration using whole blood samples from a cohort of 692 Korean adults. Sleep quality of each participant was assessed using the validated Pittsburgh Sleep Quality Index (PSQI), which encompassed seven domains: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbance, use of sleep medication, and daytime dysfunction. Four epigenetic age accelerations (HorvathAgeAccel, HannumAgeAccel, PhenoAgeAccel, and GrimAgeAccel) and the pace of aging, DunedinPACE, were investigated for epigenetic aging estimates. Results Among the 692 participants (good sleepers [n = 441, 63.7%]; poor sleepers [n = 251, 36.3%]), DunedinPACE was positively correlated with PSQI scores in poor sleepers ( $$\gamma$$ γ =0.18, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1868-7083 |
| Relation: | https://doaj.org/toc/1868-7083 |
| DOI: | 10.1186/s13148-024-01706-x |
| URL الوصول: | https://doaj.org/article/c73f7ff8406a4bb69d041be94b0e006f |
| رقم الأكسشن: | edsdoj.73f7ff8406a4bb69d041be94b0e006f |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 18687083 |
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| DOI: | 10.1186/s13148-024-01706-x |