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The effects of ARID1A mutation in gastric cancer and its significance for treatment

التفاصيل البيبلوغرافية
العنوان: The effects of ARID1A mutation in gastric cancer and its significance for treatment
المؤلفون: Shan Lu, Ruifeng Duan, Liang Cong, Ying Song
المصدر: Cancer Cell International, Vol 23, Iss 1, Pp 1-11 (2023)
بيانات النشر: BMC, 2023.
سنة النشر: 2023
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
LCC:Cytology
مصطلحات موضوعية: ARID1A mutation, Gastric cancer, Prognosis, Treatment, Biomarker, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671
الوصف: Abstract Gastric cancer (GC) has emerged as a significant issue in public health all worldwide as a result of its high mortality rate and dismal prognosis. AT-rich interactive domain 1 A (ARID1A) is a vital component of the switch/sucrose-non-fermentable (SWI/SNF) chromatin remodeling complex, and ARID1A mutations occur in various tumors, leading to protein loss and decreased expression; it then affects the tumor biological behavior or prognosis. More significantly, ARID1A mutations will likely be biological markers for immune checkpoint blockade (ICB) treatment and selective targeted therapy. To provide theoretical support for future research on the stratification of individuals with gastric cancer with ARID1A as a biomarker to achieve precision therapy, we have focused on the clinical significance, predictive value, underlying mechanisms, and possible treatment strategies for ARID1A mutations in gastric cancer in this review.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1475-2867
Relation: https://doaj.org/toc/1475-2867
DOI: 10.1186/s12935-023-03154-8
URL الوصول: https://doaj.org/article/74864162703146d3a6c2871df46c9ac5
رقم الأكسشن: edsdoj.74864162703146d3a6c2871df46c9ac5
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14752867
DOI:10.1186/s12935-023-03154-8