دورية أكاديمية
THE PRESENCE OF VARIOUS POPULATIONS OF CIRCULATING TUMOR CELLS IN THE BLOOD OF BREAST CANCER PATIENTS BEFORE TREATMENT: ASSOCIATION WITH FIVE-YEAR METASTASIS-FREE SURVIVAL
| العنوان: | THE PRESENCE OF VARIOUS POPULATIONS OF CIRCULATING TUMOR CELLS IN THE BLOOD OF BREAST CANCER PATIENTS BEFORE TREATMENT: ASSOCIATION WITH FIVE-YEAR METASTASIS-FREE SURVIVAL |
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| المؤلفون: | E. V. Kaigorodova, N. A. Tarabanovskaya, P. V. Surkova, R. V. Zelchan, E. Yu. Garbukov |
| المصدر: | Сибирский онкологический журнал, Vol 19, Iss 6, Pp 57-65 (2020) |
| بيانات النشر: | Russian Academy of Sciences, Tomsk National Research Medical Center, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | рак молочной железы, гетерогенность цок, пятилетняя безметастатическая выживаемость, циркулирующие стволовые опухолевые клетки, эпителиально-мезенхимальный переход, жидкостная биопсия, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Localized and metastatic tumors are known to lead to the formation of circulating tumor cell (CTC ) clusters in the blood. Currently, there is a heightened interest in the study of molecular and biological characteristics of CTC s. Recent studies have shown the presence of different populations of CTC s in the blood of cancer patients. Some cells are cancer stem cells, some tumor cells undergo epithelial-mesenchymal transition (EMT), and most CTC s do not have features of either stem cells or EMT.The aim of the study was to evaluate the five-year metastasis-free survival rate in patients with invasive breast carcinoma, depending on the presence of various populations of circulating tumor cells in the blood before treatment.Material and Methods. A prospective study included 47 patients with newly diagnosed invasive breast cancer (T1–4N0–3M0), who were treated at Cancer Research Institute, Tomsk National Research Medical Center. The patients aged 31 to 69 years. The presence of different populations of CTC s in the blood of patients before treatment was determined by multicolor flow cytometry on the BD FACS Canto system, using different fluorochrome-labeled monoclonal antibodies to EpCam, CD 45, CD 44, CD 24, and N-cadherin. Five-year metastasis-free survival was evaluated by the Kaplan–Meier method. The differences were considered significant at p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 1814-4861 2312-3168 |
| Relation: | https://www.siboncoj.ru/jour/article/view/1640; https://doaj.org/toc/1814-4861; https://doaj.org/toc/2312-3168 |
| DOI: | 10.21294/1814-4861-2020-19-6-57-65 |
| URL الوصول: | https://doaj.org/article/d74e00fa35214d69851ed70034ad496c |
| رقم الأكسشن: | edsdoj.74e00fa35214d69851ed70034ad496c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18144861 23123168 |
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| DOI: | 10.21294/1814-4861-2020-19-6-57-65 |