دورية أكاديمية
Recent Developments in the Treatment of Pancreatic Cancer
| العنوان: | Recent Developments in the Treatment of Pancreatic Cancer |
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| المؤلفون: | Jorge Paulino, Hélder Mansinho |
| المصدر: | Acta Médica Portuguesa, Vol 36, Iss 10 (2023) |
| بيانات النشر: | Ordem dos Médicos, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | Carcinoma, Pancreatic Ductal/drug therapy, Carcinoma, Pancreatic Ductal/surgery, Carcinoma, Pancreatic Ductal/therapy, Pancreatic Neoplasms/drug therapy, Pancreatic Neoplasms/surgery, Pancreatic Neoplasms/therapy, Medicine, Medicine (General), R5-920 |
| الوصف: | Pancreatic duct adenocarcinoma is currently the sixth-leading cause of cancer death worldwide and the fourth in Europe, with a continuous increase in annual lethality in Portugal during the last two decades. Surgical en-bloc resection of the tumor with microscopic-negative margins and an adequate lymphadenectomy is the only possibility of long-term survival. As this type of cancer is a systemic disease, there is a high rate of recurrence even after curative resection, turning systemic therapy the core of its management, mostly based on chemotherapy. Neoadjuvant strategies for nonmetastatic disease showed significant improvement in overall survival compared with upfront surgery, namely in borderline resectable disease. Moreover, these strategies provided downstaging in several situations allowing R0 resections. Under these new oncologic strategies, several recent surgical issues were introduced, namely more aggressive vascular resections and even tumor resections in oligometastatic disease. This review revisits the state-of-the-art of surgical and oncological interventions in pancreatic duct adenocarcinoma and highlights recent advances in the field aiming to achieve higher survival rates. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Portuguese |
| تدمد: | 0870-399X 1646-0758 |
| Relation: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/19957; https://doaj.org/toc/0870-399X; https://doaj.org/toc/1646-0758 |
| DOI: | 10.20344/amp.19957 |
| URL الوصول: | https://doaj.org/article/7648853487234c8da01bc742562ee696 |
| رقم الأكسشن: | edsdoj.7648853487234c8da01bc742562ee696 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 0870399X 16460758 |
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| DOI: | 10.20344/amp.19957 |