دورية أكاديمية
The utility of radiographic assessment of the internal mammary arteries in chest wall irradiated patients
| العنوان: | The utility of radiographic assessment of the internal mammary arteries in chest wall irradiated patients |
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| المؤلفون: | Vamsidhar Naraparaju, Wassim Mosleh, Mansour Almnajam, Mansour Khaddr, Swapnil Bagade, Anthony Posteraro, David Grew, Dorothy B. Wakefield, David J. Hur, Aseem Vashist |
| المصدر: | Frontiers in Bioscience-Landmark, Vol 27, Iss 1, p 030 (2022) |
| بيانات النشر: | IMR Press, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biochemistry LCC:Biology (General) |
| مصطلحات موضوعية: | internal mammary artery, ct scan, mammogram, calcification, radiotherapy, breast cancer, Biochemistry, QD415-436, Biology (General), QH301-705.5 |
| الوصف: | Purpose: The internal mammary arteries (IMA’s) are historically recognized to be protected against atherosclerosis. Whether chest wall-irradiation for breast cancer leads to significant IMA damage remains unclear. The utility of computed tomography (CT) and mammography to detect radiation-induced damage to the IMA’s and its branches is not known. The objective of this study is to assess the susceptibility of IMA’s to radiation-induced atherosclerosis, and the utility of CT scan and mammography in the assessment of IMA and its branches. Methods: A retrospective analysis of breast cancer patients who received chest wall-radiotherapy was performed. Patients with CT scans and/or mammograms ≥5 years post-radiotherapy were included. Baseline characteristics, coronary artery calcification (CAC), the presence of IMA damage assessed by CT scan, and IMA branch calcifications by mammography were recorded. Results: None of the 66 patients with CT scans post-radiotherapy revealed IMA atherosclerosis. There were 28 (42.4%) patients with CAC, of which four (14.3% of CAC subgroup or 6.1% of the total cohort) had calcifications on either side on mammogram (Chi-square test, p = 0.74). Out of the 222 patients with mammograms, 36 (16.2%) had IMA branch calcifications. Two hundred and ten patients received unilateral radiotherapy, and 27 (12.9%) of these patients had calcifications on the irradiated side, and 26 patients (12.4%) had calcifications on the contralateral side (OR = 1.0). Conclusion: IMA’s do not exhibit signs of radiation-induced atherosclerosis when evaluated by CT scan. In addition, there is no association between radiotherapy for breast cancer and the presence of IMA branch calcification on mammograms. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2768-6701 |
| Relation: | https://www.imrpress.com/journal/FBL/27/1/10.31083/j.fbl2701030; https://doaj.org/toc/2768-6701 |
| DOI: | 10.31083/j.fbl2701030 |
| URL الوصول: | https://doaj.org/article/766f2dccbe7649bda7697e1fea1918ee |
| رقم الأكسشن: | edsdoj.766f2dccbe7649bda7697e1fea1918ee |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 27686701 |
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| DOI: | 10.31083/j.fbl2701030 |