دورية أكاديمية
Characterization of the Survival Influential Genes in Carcinogenesis
| العنوان: | Characterization of the Survival Influential Genes in Carcinogenesis |
|---|---|
| المؤلفون: | Divya Sahu, Yu-Lin Chang, Yin-Chen Lin, Chen-Ching Lin |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 9, p 4384 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | survival influential genes, pan-cancer, prognostic biomarkers, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The genes influencing cancer patient mortality have been studied by survival analysis for many years. However, most studies utilized them only to support their findings associated with patient prognosis: their roles in carcinogenesis have not yet been revealed. Herein, we applied an in silico approach, integrating the Cox regression model with effect size estimated by the Monte Carlo algorithm, to screen survival-influential genes in more than 6000 tumor samples across 16 cancer types. We observed that the survival-influential genes had cancer-dependent properties. Moreover, the functional modules formed by the harmful genes were consistently associated with cell cycle in 12 out of the 16 cancer types and pan-cancer, showing that dysregulation of the cell cycle could harm patient prognosis in cancer. The functional modules formed by the protective genes are more diverse in cancers; the most prevalent functions are relevant for immune response, implying that patients with different cancer types might develop different mechanisms against carcinogenesis. We also identified a harmful set of 10 genes, with potential as prognostic biomarkers in pan-cancer. Briefly, our results demonstrated that the survival-influential genes could reveal underlying mechanisms in carcinogenesis and might provide clues for developing therapeutic targets for cancers. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/22/9/4384; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms22094384 |
| URL الوصول: | https://doaj.org/article/d7671573ba774025b8d54e11bf442fcd |
| رقم الأكسشن: | edsdoj.7671573ba774025b8d54e11bf442fcd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
|---|---|
| DOI: | 10.3390/ijms22094384 |