دورية أكاديمية
A Hydrophilic Sulfated Resveratrol Derivative for Topical Application: Sensitization and Anti-Allergic Potential
العنوان: | A Hydrophilic Sulfated Resveratrol Derivative for Topical Application: Sensitization and Anti-Allergic Potential |
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المؤلفون: | Ana Jesus, Ana I. Sebastião, Gonçalo Brites, Marta Correia-da-Silva, Honorina Cidade, Maria T. Cruz, Emília Sousa, Isabel F. Almeida |
المصدر: | Molecules, Vol 28, Iss 7, p 3158 (2023) |
بيانات النشر: | MDPI AG, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Organic chemistry |
مصطلحات موضوعية: | resveratrol, sensitization potential, anti-allergic potential, safety profile, cosmetics, Organic chemistry, QD241-441 |
الوصف: | Resveratrol (RSV), a naturally occurring metabolite, is widely used in skincare products, but its hydrophobicity impairs its own incorporation into cosmetic formulations. RSV-GS is a synthetic hydrophilic sulfated glycosylated derivative inspired by marine natural products that present a lower cytotoxicity than RSV while exhibiting similar levels of bioactivity. Herein, we predict the skin sensitization potential of this new compound using an in vitro approach based on the OECD 442E guideline. Furthermore, the anti-allergic potential of RSV-GS was also disclosed. The monocyte THP-1 cell line was stimulated with RSV and RSV-GS in the presence or absence of the extreme skin allergen 1-fluoro-2,4-dinitrobenzene (DNFB). The results demonstrated that RSV-GS alone (500 µM) evoked a relative fluorescence index (RFI) lower than the thresholds established by the OECD guideline for CD54 (200%) and CD86 (150%), indicating the absence of a skin sensitization potential. Interestingly, in the presence of the skin allergen DNFB, RSV-GS exhibited the ability to rescue the DNFB-induced maturation of THP-1 cells, with RFI values lower than those for RSV, suggesting the potential of RSV-GS to mitigate skin sensitization evoked by allergens and, consequently, allergic contact dermatitis. These results open new avenues for the use of RSV-GS as a safe and anti-allergic active cosmetic ingredient. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1420-3049 |
Relation: | https://www.mdpi.com/1420-3049/28/7/3158; https://doaj.org/toc/1420-3049 |
DOI: | 10.3390/molecules28073158 |
URL الوصول: | https://doaj.org/article/786e965f4bc543d9af29afec80e6b6dd |
رقم الأكسشن: | edsdoj.786e965f4bc543d9af29afec80e6b6dd |
قاعدة البيانات: | Directory of Open Access Journals |
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