دورية أكاديمية
The characterization of tumor microenvironment infiltration and the construction of predictive index based on cuproptosis-related gene in primary lung adenocarcinoma
| العنوان: | The characterization of tumor microenvironment infiltration and the construction of predictive index based on cuproptosis-related gene in primary lung adenocarcinoma |
|---|---|
| المؤلفون: | Kun Li, Lei-Lei Wu, Hui Wang, Hao Cheng, Hui-Min Zhuo, Yun Hao, Zhi-Yuan Liu, Chong-Wu Li, Jia-Yi Qian, Zhi-Xin Li, Dong Xie, Chang Chen |
| المصدر: | Frontiers in Oncology, Vol 12 (2022) |
| بيانات النشر: | Frontiers Media S.A., 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | cuproptosis-related gene, lung adenocarcinoma, prognosis, immunotherapy, targeted therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | ObjectiveWe aimed to use the cancer genome atlas and gene expression omnibus databases to explore the characterization of tumor microenvironment (TME) infiltration and construct a predictive index of prognosis and treatment effect based on cuproptosis-related genes (CRGs) in primary lung adenocarcinoma (LUAD).MethodsWe described the alterations of CRGs in 954 LUAD samples from genetic and transcriptional fields and evaluated their expression patterns from three independent datasets. We identified two distinct molecular subtypes and found that multi-layer CRG alterations were correlated with patient clinicopathological features, prognosis, and TME cell infiltrating characteristics. Then, a cuproptosis scoring system (CSS) for predicting the prognosis was constructed, and its predictive capability in LUAD patients was validated.ResultsTwo molecular subtypes of cuproptosis (Copper Genes cluster A and cluster B) in LUAD were identified. Copper Genes cluster B had better survival than those with Copper Genes cluster A (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2234-943X |
| Relation: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1011568/full; https://doaj.org/toc/2234-943X |
| DOI: | 10.3389/fonc.2022.1011568 |
| URL الوصول: | https://doaj.org/article/aadce7915a4146e1836052c52cc3a5ca |
| رقم الأكسشن: | edsdoj.7915a4146e1836052c52cc3a5ca |
| قاعدة البيانات: | Directory of Open Access Journals |
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