دورية أكاديمية
Association between triglyceride to high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease and liver fibrosis in American adults: an observational study from the National Health and Nutrition Examination Survey 2017–2020
العنوان: | Association between triglyceride to high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease and liver fibrosis in American adults: an observational study from the National Health and Nutrition Examination Survey 2017–2020 |
---|---|
المؤلفون: | Jianjun Wang, Han Li, Xiaoyi Wang, Ruizi Shi, Junchao Hu, Xintao Zeng, Hua Luo, Pei Yang, Huiwen Luo, Yuan Cao, Xianfu Cai, Sirui Chen, Decai Wang |
المصدر: | Frontiers in Endocrinology, Vol 15 (2024) |
بيانات النشر: | Frontiers Media S.A., 2024. |
سنة النشر: | 2024 |
المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
مصطلحات موضوعية: | National health and nutrition examination survey, nonalcoholic fatty liver disease, cross-sectional study, triglyceride to high-density lipoprotein cholesterol ratio, liver fibrosis, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
الوصف: | ObjectiveThis study investigated the link between triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and nonalcoholic fatty liver disease (NAFLD) and liver fibrosis in American adults.MethodsInformation for 6495 participants from the National Health and Nutrition Examination Survey (NHANES) 2017–2020.03 was used for this cross-sectional study. The link between TG/HDL-C ratios and NAFLD and liver fibrosis was assessed by multiple linear regression before evaluating nonlinear correlations based on smoothed curve fitting models. Stratification analysis was then applied to confirm whether the dependent and independent variables displayed a stable association across populations.ResultsTG/HDL-C ratios were positively correlated with NAFLD, with higher ratios being linked to increased prevalence of NAFLD. After adjusting for potential confounders, the odds ratios (OR) for NAFLD patients in the fourth TG/HDL-C quartile were 3.61 (95% confidence interval [CI], 2.94–4.38) (P for trend < 0.001) in comparison with those in the first quartile after adjusting for clinical variables. However, no statistical significance was noted for the ratio for liver fibrosis after adjusting for potential confounders (P for trend = 0.07). A nonlinear correlation between TG/HDL-C ratios and NAFLD was observed based on smoothed curve fitting models. However, a nonlinear relationship between the ratios and liver fibrosis was not established. In subgroup analyses, there was an interaction between smoking status and TG/HDL-C ratio in relation to the prevalence of liver fibrosis (P for interaction < 0.001).ConclusionsAmong American adults, the TG/HDL-C ratio was noted to be nonlinearly positively associated with the prevalence of NAFLD; however, this relationship was not present in liver fibrosis. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1664-2392 |
Relation: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1362396/full; https://doaj.org/toc/1664-2392 |
DOI: | 10.3389/fendo.2024.1362396 |
URL الوصول: | https://doaj.org/article/79a6b0e39dfb44f3b2b72d93bd5dadc7 |
رقم الأكسشن: | edsdoj.79a6b0e39dfb44f3b2b72d93bd5dadc7 |
قاعدة البيانات: | Directory of Open Access Journals |
كن أول من يترك تعليقا!