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New onset diabetes mellitus and cardiovascular events in Korean patients with acute myocardial infarction receiving high-intensity statins

التفاصيل البيبلوغرافية
العنوان: New onset diabetes mellitus and cardiovascular events in Korean patients with acute myocardial infarction receiving high-intensity statins
المؤلفون: Jah Yeon Choi, Cheol Ung Choi, Byoung Geol Choi, Yoonjee Park, Dong Oh Kang, Won Young Jang, Woohyeun Kim, Jin Oh Na, Jin Won Kim, Eung Ju Kim, Seung-Woon Rha, Chang Gyu Park, Hong Seog Seo, Myung Ho Jeong, Sung-Chull Chae, In-Whan Seong, Chang-Hwan Yoon, Kwang Soo Cha, Seok Kyu Oh, KAMIR-NIH Investigators
المصدر: BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-7 (2021)
بيانات النشر: BMC, 2021.
سنة النشر: 2021
المجموعة: LCC:Therapeutics. Pharmacology
LCC:Toxicology. Poisons
مصطلحات موضوعية: Acute myocardial infarction, New-onset diabetes mellitus, Cardiovascular outcome, Atorvastatin, Rosuvastatin, Therapeutics. Pharmacology, RM1-950, Toxicology. Poisons, RA1190-1270
الوصف: Abstract Background High-intensity statin therapy is typically used in patients with acute myocardial infarction (AMI) for secondary prevention. However, there have been consistent concerns regarding its association with diabetes mellitus. We investigated the effect of high-intensity atorvastatin and rosuvastatin on new-onset diabetes mellitus (NODM) and cardiovascular outcomes over a 3-year follow-up period. Methods Data from the Korea Acute Myocardial Infarction Registry were collected from November 2011 to October 2015, and 13,104 patients with AMI were enrolled from major cardiovascular centers. Among them, 2221 patients without diabetes who had been administered with high-intensity atorvastatin (40–80 mg) and rosuvastatin (20 mg) were investigated. The atorvastatin and rosuvastatin groups were evaluated for the incidence of NODM and major adverse cardiac events (MACE) including death, myocardial infarction, and revascularization cases in the following 3 years. Results Baseline characteristics were comparable between the two groups. Event-free survival rate of NODM was not significantly different between the atorvastatin and rosuvastatin groups (92.5% vs. 90.8%, respectively; Log-rank P-value = 0.550). The event-free survival rate of MACE was also not significantly different between atorvastatin and rosuvastatin groups (89.0% vs. 89.6%, respectively; Log rank P-value = 0.662). Multivariate Cox analysis revealed that statin type was not a prognostic factor in the development of NODM and MACE. Conclusions Administering high-intensity atorvastatin and rosuvastatin in patients with AMI produced comparable effects on NODM and clinical outcomes, suggesting their clinical equivalence in secondary prevention.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-6511
Relation: https://doaj.org/toc/2050-6511
DOI: 10.1186/s40360-021-00476-z
URL الوصول: https://doaj.org/article/79a923a0d31540e18e42aeb1f2ec5595
رقم الأكسشن: edsdoj.79a923a0d31540e18e42aeb1f2ec5595
قاعدة البيانات: Directory of Open Access Journals
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