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أعرض في EDS

Direct-Acting Antiviral Therapy in Liver Transplant Patients With Hepatocellular Carcinoma and Hepatitis C

التفاصيل البيبلوغرافية
العنوان: Direct-Acting Antiviral Therapy in Liver Transplant Patients With Hepatocellular Carcinoma and Hepatitis C
المؤلفون: Chung Sang Tse, Ju Dong Yang, Omar Y. Mousa, Kevin M. Nelson, Surakit Pungpapong, Andrew Keaveny, Bashar A. Aqel, Hugo Vargas, Rolland C. Dickson, Kymberly Watt, Gregory J. Gores, Lewis R. Roberts, Michael D. Leise
المصدر: Transplantation Direct, Vol 7, Iss 1, p e635 (2021)
بيانات النشر: Wolters Kluwer, 2021.
سنة النشر: 2021
المجموعة: LCC:Surgery
مصطلحات موضوعية: Surgery, RD1-811
الوصف: Background:. Direct-acting antivirals (DAA) are highly effective for the treatment of hepatitis C (HCV), although there are limited data on the safety and efficacy of DAA therapy in hepatitis C-positive individuals awaiting liver transplantation for hepatocellular carcinoma (HCC). Methods:. We conducted a retrospective cohort study of HCV-positive patients who underwent liver transplantation for HCC at 3 liver transplant centers across the United States from 2014 to 2017 with follow-up to July 2018. Transplant recipients who received DAA before transplant were compared with those who did not (DAA naive) for posttransplant HCC recurrence rate, sustained virological response (SVR), allograft failure, and death using Kaplan-Meier analysis and Cox proportional hazard models. Results:. A total of 171 HCV-HCC transplant recipients (99 pretransplant DAA; 72 DAA naive controls) were included, with a median follow-up of 24 months. The overall posttransplant HCC recurrence rate was 9% (15/171). Pretransplant DAA was not associated with HCC recurrence (5% versus 14%; P = 0.07), graft failure (7% versus 3%; P = 0.21), or death (12% versus 19%; P = 0.19) as compared with DAA naive patients. SVR rates were significantly lower (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2373-8731
00000000
Relation: http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001049; https://doaj.org/toc/2373-8731
DOI: 10.1097/TXD.0000000000001049
URL الوصول: https://doaj.org/article/7c2475419c2d4b9da3a2dcf46f196f33
رقم الأكسشن: edsdoj.7c2475419c2d4b9da3a2dcf46f196f33
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23738731
00000000
DOI:10.1097/TXD.0000000000001049