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Nociceptive interneurons control modular motor pathways to promote escape behavior in Drosophila

التفاصيل البيبلوغرافية
العنوان: Nociceptive interneurons control modular motor pathways to promote escape behavior in Drosophila
المؤلفون: Anita Burgos, Ken Honjo, Tomoko Ohyama, Cheng Sam Qian, Grace Ji-eun Shin, Daryl M Gohl, Marion Silies, W Daniel Tracey, Marta Zlatic, Albert Cardona, Wesley B Grueber
المصدر: eLife, Vol 7 (2018)
بيانات النشر: eLife Sciences Publications Ltd, 2018.
سنة النشر: 2018
المجموعة: LCC:Medicine
LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: nociception, sensory circuit, sensory neuron, behavior, interneuron, larva, Medicine, Science, Biology (General), QH301-705.5
الوصف: Rapid and efficient escape behaviors in response to noxious sensory stimuli are essential for protection and survival. Yet, how noxious stimuli are transformed to coordinated escape behaviors remains poorly understood. In Drosophila larvae, noxious stimuli trigger sequential body bending and corkscrew-like rolling behavior. We identified a population of interneurons in the nerve cord of Drosophila, termed Down-and-Back (DnB) neurons, that are activated by noxious heat, promote nociceptive behavior, and are required for robust escape responses to noxious stimuli. Electron microscopic circuit reconstruction shows that DnBs are targets of nociceptive and mechanosensory neurons, are directly presynaptic to pre-motor circuits, and link indirectly to Goro rolling command-like neurons. DnB activation promotes activity in Goro neurons, and coincident inactivation of Goro neurons prevents the rolling sequence but leaves intact body bending motor responses. Thus, activity from nociceptors to DnB interneurons coordinates modular elements of nociceptive escape behavior.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-084X
Relation: https://elifesciences.org/articles/26016; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.26016
URL الوصول: https://doaj.org/article/7c7d91a80d1d4f9684a3d7e21c07ce0a
رقم الأكسشن: edsdoj.7c7d91a80d1d4f9684a3d7e21c07ce0a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2050084X
DOI:10.7554/eLife.26016