دورية أكاديمية
Pannorin isolated from marine Penicillium sp. SG-W3: a selective monoamine oxidase A inhibitor
| العنوان: | Pannorin isolated from marine Penicillium sp. SG-W3: a selective monoamine oxidase A inhibitor |
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| المؤلفون: | Jong Min Oh, Qian Gao, Woong-Hee Shin, Eun-Young Lee, Dawoon Chung, Grace Choi, Sang-Jip Nam, Hoon Kim |
| المصدر: | Applied Biological Chemistry, Vol 67, Iss 1, Pp 1-12 (2024) |
| بيانات النشر: | SpringerOpen, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Agriculture (General) LCC:Chemistry |
| مصطلحات موضوعية: | Penicillium sp. SG-W3, Pannorin, Monoamine oxidase, Enzyme kinetics, Reversible competitive inhibitor, Molecular docking and dynamics, Agriculture (General), S1-972, Chemistry, QD1-999 |
| الوصف: | Abstract Six compounds were isolated from Penicillium sp. SG-W3, a marine-derived fungus, and their inhibitory activities against target enzymes relating to neurological diseases were evaluated. Compound 1 (pannorin) was a potent and selective monoamine oxidase (MAO)-A inhibitor with a 50% inhibitory concentration (IC50) of 1.734 μM and a selectivity index (SI) of > 23.07 versus MAO-B, and it showed an efficient antioxidant activity. All compounds showed weak inhibitory activities against acetylcholinesterase, butyrylcholinesterase, and β-secretase. The inhibition constant (Ki) of 1 for MAO-A was 1.049 ± 0.030 μM with competitive inhibition. Molecular docking simulation predicted that compound 1 forms hydrogen bonds with MAO-A, and binds more tightly to MAO-A than to MAO-B (− 25.02 and − 24.06 kcal/mol, respectively). These results suggest that compound 1 is a selective, reversible, and competitive MAO-A inhibitor that can be a therapeutic candidate for treating neurological diseases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2468-0842 |
| Relation: | https://doaj.org/toc/2468-0842 |
| DOI: | 10.1186/s13765-024-00878-7 |
| URL الوصول: | https://doaj.org/article/d7f18b775b054623906d6221aae2ad70 |
| رقم الأكسشن: | edsdoj.7f18b775b054623906d6221aae2ad70 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 24680842 |
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| DOI: | 10.1186/s13765-024-00878-7 |