دورية أكاديمية
Dendritic Spines and Development: Towards a Unifying Model of Spinogenesis—A Present Day Review of Cajal's Histological Slides and Drawings
العنوان: | Dendritic Spines and Development: Towards a Unifying Model of Spinogenesis—A Present Day Review of Cajal's Histological Slides and Drawings |
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المؤلفون: | Pablo García-López, Virginia García-Marín, Miguel Freire |
المصدر: | Neural Plasticity, Vol 2010 (2010) |
بيانات النشر: | Wiley, 2010. |
سنة النشر: | 2010 |
المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
مصطلحات موضوعية: | Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
الوصف: | Dendritic spines receive the majority of excitatory connections in the central nervous system, and, thus, they are key structures in the regulation of neural activity. Hence, the cellular and molecular mechanisms underlying their generation and plasticity, both during development and in adulthood, are a matter of fundamental and practical interest. Indeed, a better understanding of these mechanisms should provide clues to the development of novel clinical therapies. Here, we present original results obtained from high-quality images of Cajal's histological preparations, stored at the Cajal Museum (Instituto Cajal, CSIC), obtained using extended focus imaging, three-dimensional reconstruction, and rendering. Based on the data available in the literature regarding the formation of dendritic spines during development and our results, we propose a unifying model for dendritic spine development. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2090-5904 1687-5443 |
Relation: | https://doaj.org/toc/2090-5904; https://doaj.org/toc/1687-5443 |
DOI: | 10.1155/2010/769207 |
URL الوصول: | https://doaj.org/article/7fd93716dee4494ba1168dfffc111c0b |
رقم الأكسشن: | edsdoj.7fd93716dee4494ba1168dfffc111c0b |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 20905904 16875443 |
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DOI: | 10.1155/2010/769207 |