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Guidelines for performing Mendelian randomization investigations: update for summer 2023 [version 3; peer review: 2 approved]

التفاصيل البيبلوغرافية
العنوان: Guidelines for performing Mendelian randomization investigations: update for summer 2023 [version 3; peer review: 2 approved]
المؤلفون: Frank Dudbridge, Caroline L. Relton, George Davey Smith, Jean V. Morrison, Zoltán Kutalik, Stephen Burgess, Wei Pan, Dipender Gill, Neil M. Davies, Fernando P. Hartwig, M. Maria Glymour, Cosetta Minelli, Michael V. Holmes, Evropi Theodoratou
المصدر: Wellcome Open Research, Vol 4 (2023)
بيانات النشر: Wellcome, 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Mendelian randomization, guidelines, genetic epidemiology, causal inference, eng, Medicine, Science
الوصف: This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into ten sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), extensions and additional analyses, data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 24 months.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2398-502X
Relation: https://wellcomeopenresearch.org/articles/4-186/v3; https://doaj.org/toc/2398-502X
DOI: 10.12688/wellcomeopenres.15555.3
URL الوصول: https://doaj.org/article/82b37d8db5fc43c1b241b7d611f55b1d
رقم الأكسشن: edsdoj.82b37d8db5fc43c1b241b7d611f55b1d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2398502X
DOI:10.12688/wellcomeopenres.15555.3