دورية أكاديمية
Retinoblastoma: An update on genetic origin, classification, conventional to next-generation treatment strategies
| العنوان: | Retinoblastoma: An update on genetic origin, classification, conventional to next-generation treatment strategies |
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| المؤلفون: | Ashutosh Pareek, Deepanjali Kumar, Aaushi Pareek, Madan Mohan Gupta, Philippe Jeandet, Yashumati Ratan, Vivek Jain, Mohammad Amjad Kamal, Muhammad Saboor, Ghulam Md Ashraf, Anil Chuturgoon |
| المصدر: | Heliyon, Vol 10, Iss 12, Pp e32844- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Retinoblastoma, Paediatric, Quadrilateral retinoblastoma, Nanostructured drug delivery systems, Gene therapy, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | The most prevalent paediatric vision-threatening medical condition, retinoblastoma (RB), has been a global concern for a long time. Several conventional therapies, such as systemic chemotherapy and focal therapy, have been used for curative purposes; however, the search for tumour eradication with the least impact on surrounding tissues is still ongoing. This review focuses on the genetic origin, classification, conventional treatment modalities, and their combination with nano-scale delivery systems for active tumour targeting. In addition, the review also delves into ongoing clinical trials and patents, as well as emerging therapies such as gene therapy and immunotherapy for the treatment of RB. Understanding the role of genetics in the development of RB has refined its treatment strategy according to the genetic type. New approaches such as nanostructured drug delivery systems, galenic preparations, nutlin-3a, histone deacetylase inhibitors, N-MYC inhibitors, pentoxifylline, immunotherapy, gene therapy, etc. discussed in this review, have the potential to circumvent the limitations of conventional therapies and improve treatment outcomes for RB. In summary, this review highlights the importance and need for novel approaches as alternative therapies that would ultimately displace the shortcomings associated with conventional therapies and reduce the enucleation rate, thereby preserving global vision in the affected paediatric population. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844024088753; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2024.e32844 |
| URL الوصول: | https://doaj.org/article/8330a1a534914bd8953e7d2aca1dbffb |
| رقم الأكسشن: | edsdoj.8330a1a534914bd8953e7d2aca1dbffb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2024.e32844 |