دورية أكاديمية
Generation and characterization of induced pluripotent stem cell lines derived from skin fibroblasts of patients with adrenoleukodystrophy
العنوان: | Generation and characterization of induced pluripotent stem cell lines derived from skin fibroblasts of patients with adrenoleukodystrophy |
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المؤلفون: | Qiu-Hong Wang, Li-Ying Liu, Yang-Yang Wang, Wen He, Jia Wang, Jing Wang, Li-Ping Zou |
المصدر: | Stem Cell Research, Vol 73, Iss , Pp 103243- (2023) |
بيانات النشر: | Elsevier, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Biology (General) |
مصطلحات موضوعية: | Biology (General), QH301-705.5 |
الوصف: | X-linked adrenoleukodystrophy (ALD) is a rare peroxisome disease with phenotypic heterogeneity. There is a lack of suitable in vitro models to study its pathogenesis. We established two strains of iPSCs from skin fibroblasts of patients with childhood cerebral ALD and Addison’s disease, respectively. CytoTune™2.0 Sendai reprogramming kit was used. The iPSC lines showed typical stem cell morphology, normal karyotype, and carrying ABCD1 variation. The iPSC lines express pluripotency markers, and have the capacity to differentiate into three germ layers. iPSCs can be used as an alternative cell source for ALD in vitro model to study its pathogenesis and therapeutic strategies. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1873-5061 |
Relation: | http://www.sciencedirect.com/science/article/pii/S1873506123002295; https://doaj.org/toc/1873-5061 |
DOI: | 10.1016/j.scr.2023.103243 |
URL الوصول: | https://doaj.org/article/a8359cb4e5d54001b75fa19b0cb048a3 |
رقم الأكسشن: | edsdoj.8359cb4e5d54001b75fa19b0cb048a3 |
قاعدة البيانات: | Directory of Open Access Journals |
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