دورية أكاديمية

Amelioration of alcohol-induced acute liver injury in C57BL/6 mice by a mixture of TCM phytochemicals and probiotics with antioxidative and anti-inflammatory effects

التفاصيل البيبلوغرافية
العنوان: Amelioration of alcohol-induced acute liver injury in C57BL/6 mice by a mixture of TCM phytochemicals and probiotics with antioxidative and anti-inflammatory effects
المؤلفون: Zhiguo Li, Xuexun Fang, Xin Hu, Congcong Li, Youzhong Wan, Dahai Yu
المصدر: Frontiers in Nutrition, Vol 10 (2023)
بيانات النشر: Frontiers Media S.A., 2023.
سنة النشر: 2023
المجموعة: LCC:Nutrition. Foods and food supply
مصطلحات موضوعية: TCM, phytochemicals, liver injury, probiotics, anti-oxidation, anti-inflammation, Nutrition. Foods and food supply, TX341-641
الوصف: BackgroundThere are many causes of acute liver injury (ALI), such as alcohol, drugs, infection, and toxic materials, which have caused major health problems around the world. Among these causes, alcohol consumption induced liver injury is a common alcoholic liver disease, which can further lead to liver failure even liver cancer. A number of traditional Chinese medicine (TCM) and TCM derived compounds have been used in treating the liver-associated diseases and combination use of probiotics with TCM phytochemicals has attracted interests for enhanced biological effects.MethodsThis study investigated the hepatoprotective effect of TCM-probiotics complex (TCMPC) and its underlying mechanism for the treatment of ALI in mice. The TCMPC is composed of TCM phytochemicals puerarin, curcumin, ginsenosides, and 5 lactobacteria strains. We first established a mouse model of alcohol-induced ALI, then the therapeutic effects of TCMPC on alcohol-induced ALI were monitored. A series of measurements have been performed on antioxidation, anti-inflammation, and lipid metabolism regulation.ResultsThe results showed that TCMPC can reduce the level of liver injury biomarkers and regulate oxidative stress. Histopathological results indicated that TCMPC could ameliorate ALI in mice. In addition, it can also significantly reduce the production of inflammatory cytokines caused by ALI.ConclusionOur research has proved the therapeutic effect of TCMPC on alcohol-induced ALI. The potential mechanism of hepatoprotective effects of TCMPC may be related to its antioxidative and anti-inflammatory effects. Our research might provide a new way for liver disease treatment.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2296-861X
Relation: https://www.frontiersin.org/articles/10.3389/fnut.2023.1144589/full; https://doaj.org/toc/2296-861X
DOI: 10.3389/fnut.2023.1144589
URL الوصول: https://doaj.org/article/847c27a6302a43609dee7ae4a59506dd
رقم الأكسشن: edsdoj.847c27a6302a43609dee7ae4a59506dd
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2296861X
DOI:10.3389/fnut.2023.1144589