دورية أكاديمية
Differential alternative splicing between hepatocellular carcinoma with normal and elevated serum alpha-fetoprotein
| العنوان: | Differential alternative splicing between hepatocellular carcinoma with normal and elevated serum alpha-fetoprotein |
|---|---|
| المؤلفون: | Young-Joo Jin, Habtamu Minassie Aycheh, Seonggyun Han, John Chamberlin, Jaehang Shin, Seyoun Byun, Younghee Lee |
| المصدر: | BMC Medical Genomics, Vol 13, Iss S11, Pp 1-11 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Internal medicine LCC:Genetics |
| مصطلحات موضوعية: | Hepatocellular carcinoma, Alpha-fetoprotein, Alternative splicing, RNA-sequencing, Internal medicine, RC31-1245, Genetics, QH426-470 |
| الوصف: | Abstract Background Serum alpha-fetoprotein (AFP) is the approved serum marker for hepatocellular carcinoma (HCC) screening. However, not all HCC patients show high (≥ 20 ng/mL) serum AFP, and the molecular mechanisms of HCCs with normal ( 0.05, FDR 0.05), in which exons 25 and 33 were more frequently skipped in HCCs with normal (low) serum AFP compared to those with high serum AFP. Moreover, these events were gender and VI dependent. Conclusion We found that AS may influence the regulation of transcriptional differences inherent in the occurrence of HCC maintaining normal rather than elevated serum AFP levels. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1755-8794 |
| Relation: | https://doaj.org/toc/1755-8794 |
| DOI: | 10.1186/s12920-020-00836-4 |
| URL الوصول: | https://doaj.org/article/85a367f4098b443d9259df998ca40b5b |
| رقم الأكسشن: | edsdoj.85a367f4098b443d9259df998ca40b5b |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 17558794 |
|---|---|
| DOI: | 10.1186/s12920-020-00836-4 |