دورية أكاديمية
Towards medical imaging of drug photoactivation: Development of light responsive magnetic resonance imaging and chemical exchange saturation transfer contrast agents
| العنوان: | Towards medical imaging of drug photoactivation: Development of light responsive magnetic resonance imaging and chemical exchange saturation transfer contrast agents |
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| المؤلفون: | Ilse M. Welleman, Carlijn L. F. vanBeek, Ioana Belcin, Albert M. Schulte, Rudi A. J. O. Dierckx, Ben L. Feringa, Hendrikus H. Boersma, Wiktor Szymański |
| المصدر: | Smart Molecules, Vol 2, Iss 2, Pp n/a-n/a (2024) |
| بيانات النشر: | Wiley, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | CEST, MRI, photochemistry, photocleavable protecting groups, photopharmacology, Chemistry, QD1-999 |
| الوصف: | Abstract In recent years, the use of light to selectively and precisely activate drugs has been developed along the fundamental concepts of photopharmacology. One of the key methods in this field relies on transiently silencing the drug activity with photocleavable protecting groups (PPGs). To effectively utilize light‐activated drugs in future medical applications, physicians will require a reliable method to assess whether light penetrates deep enough into the tissues to activate the photoresponsive theragnostic agents. Here, we describe the development and evaluation of magnetic resonance (MR) imaging agents that allow for the detection of light penetration and drug activation in the tissues using non‐invasive whole‐body magnetic resonance imaging (MRI) and chemical exchange saturation transfer (CEST)‐MRI modalities. The approach relies on the use of PPG‐protected MR contrast agents, which upon irradiation with light change their imaging signal. A Gadolinium(III)‐based MRI contrast agent is presented that undergoes a significant change in relaxivity (25%) upon uncaging, providing a reliable indicator of light‐induced cargo release. Additionally, we introduce the first light‐responsive CEST‐MRI imaging agent, enabling positive signal enhancement (off‐to‐on) upon light activation, offering a novel approach to visualize the activation of photoactive agents in living tissues. This research provides a proof‐of‐principle for the non‐invasive, whole‐body imaging of light penetration and drug activation with high temporal resolution characteristic of MR methods. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2751-4595 2751-4587 |
| Relation: | https://doaj.org/toc/2751-4587; https://doaj.org/toc/2751-4595 |
| DOI: | 10.1002/smo.20230029 |
| URL الوصول: | https://doaj.org/article/887ca37dba4d4b718855707bb232936d |
| رقم الأكسشن: | edsdoj.887ca37dba4d4b718855707bb232936d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 27514595 27514587 |
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| DOI: | 10.1002/smo.20230029 |