دورية أكاديمية
Resveratrol Supplementation Prevents Hypertension in Hypertensive Pregnant Rats by Increasing Sodium Excretion and Serum Nitric Oxide Level
العنوان: | Resveratrol Supplementation Prevents Hypertension in Hypertensive Pregnant Rats by Increasing Sodium Excretion and Serum Nitric Oxide Level |
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المؤلفون: | Xiaowen Jia, Rong Zhang, Jinzhu Guo, Hua Yue, Qiuxia Liu, Lipei Guo, Qunchang Zhang |
المصدر: | International Journal of Hypertension, Vol 2020 (2020) |
بيانات النشر: | Wiley, 2020. |
سنة النشر: | 2020 |
المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
مصطلحات موضوعية: | Diseases of the circulatory (Cardiovascular) system, RC666-701 |
الوصف: | Background. Pregnancy-induced hypertension (PIH) remains a major cause of morbidity and mortality in pregnancy worldwide. This study was designed to study the blood pressure-lowering effect of resveratrol (RES) in a salt-induced hypertensive pregnant rat model. Methods. Forty female Sprague Dawley (SD) rats were randomized into 4 groups: Normal Preg (0.9% salt diet), Normal Preg + RES (0.9% salt diet plus daily oral RES for 4 weeks), Salt Preg (8% salt diet), and Salt Preg + RES (8% salt diet plus daily oral RES for 4 weeks). Noninvasive blood pressure was recorded on gestational days 7 and 14. On the gestational day 19, foetuses were weighed, and blood and urine samples were harvested for electrolytes and biochemical assays. Results. RES significantly reduced SBP, DBP, and MAP on gestational days 7 and 14 in the Salt Preg + RES group compared to the Salt Preg group (all P |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2090-0384 2090-0392 |
Relation: | https://doaj.org/toc/2090-0384; https://doaj.org/toc/2090-0392 |
DOI: | 10.1155/2020/4154010 |
URL الوصول: | https://doaj.org/article/8b45b6938e3e4391a192d25e7f0b29e6 |
رقم الأكسشن: | edsdoj.8b45b6938e3e4391a192d25e7f0b29e6 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 20900384 20900392 |
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DOI: | 10.1155/2020/4154010 |