دورية أكاديمية
Deep Brain Stimulation of the Pedunculopontine Tegmental Nucleus Renders Neuroprotection through the Suppression of Hippocampal Apoptosis: An Experimental Animal Study
| العنوان: | Deep Brain Stimulation of the Pedunculopontine Tegmental Nucleus Renders Neuroprotection through the Suppression of Hippocampal Apoptosis: An Experimental Animal Study |
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| المؤلفون: | Chellappan Praveen Rajneesh, Tsung-Hsun Hsieh, Shih-Ching Chen, Chien-Hung Lai, Ling-Yu Yang, Hung-Yen Chin, Chih-Wei Peng |
| المصدر: | Brain Sciences, Vol 10, Iss 1, p 25 (2020) |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: | pptg-dbs, bdnf, caspase-3, lipid peroxidation, hippocampus, apoptosis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | The core objective of this study was to determine the neuroprotective properties of deep brain stimulation of the pedunculopontine tegmental nucleus on the apoptosis of the hippocampus. The pedunculopontine tegmental nucleus is a prime target for Parkinson′s disease and is a crucial component in a feedback loop connected with the hippocampus. Deep brain stimulation was employed as a potential tool to evaluate the neuroprotective properties of hippocampal apoptosis. Deep brain stimulation was applied to the experimental animals for an hour. Henceforth, the activity of Caspase-3, myelin basic protein, Bcl-2, BAX level, lipid peroxidation, interleukin-6 levels, and brain-derived neurotrophic factor levels were evaluated at hours 1, 3 and 6 and compared with the sham group of animals. Herein, decreased levels of caspases activity and elevated levels of Bcl-2 expressions and inhibited BAX expressions were observed in experimental animals at the aforementioned time intervals. Furthermore, the ratio of Bcl-2/BAX was increased, and interleukin -6, lipid peroxidation levels were not affected by deep brain stimulation in the experimental animals. These affirmative results have explained the neuroprotection rendered by hippocampus apoptosis as a result of deep brain stimulation. Deep brain stimulation is widely used to manage neuro-motor disorders. Nevertheless, this novel study will be a revelation for a better understanding of neuromodulatory management and encourage further research with new dimensions in the field of neuroscience. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2076-3425 10010025 |
| Relation: | https://www.mdpi.com/2076-3425/10/1/25; https://doaj.org/toc/2076-3425 |
| DOI: | 10.3390/brainsci10010025 |
| URL الوصول: | https://doaj.org/article/8b928146106a49319c0a5d5331a4a146 |
| رقم الأكسشن: | edsdoj.8b928146106a49319c0a5d5331a4a146 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20763425 10010025 |
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| DOI: | 10.3390/brainsci10010025 |