دورية أكاديمية
Guardians and Mediators of Metastasis: Exploring T Lymphocytes, Myeloid-Derived Suppressor Cells, and Tumor-Associated Macrophages in the Breast Cancer Microenvironment
| العنوان: | Guardians and Mediators of Metastasis: Exploring T Lymphocytes, Myeloid-Derived Suppressor Cells, and Tumor-Associated Macrophages in the Breast Cancer Microenvironment |
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| المؤلفون: | Maria Rosaria Ruocco, Armando Gisonna, Vittoria Acampora, Anna D’Agostino, Barbara Carrese, Jessie Santoro, Alessandro Venuta, Rosarita Nasso, Nicola Rocco, Daniela Russo, Annachiara Cavaliere, Giovanna Giuseppina Altobelli, Stefania Masone, Angelica Avagliano, Alessandro Arcucci, Giuseppe Fiume |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 11, p 6224 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | breast cancers, tumor microenvironment, tumor-infiltrating lymphocytes, tumor-associated macrophages, myeloid-derived suppressor cells, metastasis, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Breast cancers (BCs) are solid tumors composed of heterogeneous tissues consisting of cancer cells and an ever-changing tumor microenvironment (TME). The TME includes, among other non-cancer cell types, immune cells influencing the immune context of cancer tissues. In particular, the cross talk of immune cells and their interactions with cancer cells dramatically influence BC dissemination, immunoediting, and the outcomes of cancer therapies. Tumor-infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), and myeloid-derived suppressor cells (MDSCs) represent prominent immune cell populations of breast TMEs, and they have important roles in cancer immunoescape and dissemination. Therefore, in this article we review the features of TILs, TAMs, and MDSCs in BCs. Moreover, we highlight the mechanisms by which these immune cells remodel the immune TME and lead to breast cancer metastasis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/25/11/6224; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms25116224 |
| URL الوصول: | https://doaj.org/article/d8d06e80e47141f586c1d5becfe092ec |
| رقم الأكسشن: | edsdoj.8d06e80e47141f586c1d5becfe092ec |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25116224 |